U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DCSTAMP dendrocyte expressed seven transmembrane protein [ Homo sapiens (human) ]

Gene ID: 81501, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
DCSTAMPprovided by HGNC
Official Full Name
dendrocyte expressed seven transmembrane proteinprovided by HGNC
Primary source
HGNC:HGNC:18549
See related
Ensembl:ENSG00000164935 MIM:605933; AllianceGenome:HGNC:18549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIND; TM7SF4; hDC-STAMP
Summary
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Expression
Biased expression in lung (RPKM 1.3), liver (RPKM 0.2) and 4 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DCSTAMP in Genome Data Viewer
Location:
8q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (104339796..104356689)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (105466609..105484210)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (105352024..105368917)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:105295895-105296650 Neighboring gene uncharacterized LOC107986899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27794 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:105354631-105355179 Neighboring gene NANOG hESC enhancer GRCh37_chr8:105362981-105363482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27796 Neighboring gene dihydropyrimidinase Neighboring gene ReSE screen-validated silencer GRCh37_chr8:105439574-105439765 Neighboring gene uncharacterized LOC105375692 Neighboring gene uncharacterized LOC105375691 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:105481037-105482236 Neighboring gene MPRA-validated peak7134 silencer

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. New prescription for some leftover drugs. . Harv Heart Lett, 2010 Mar. PMID 20586129
  2. Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget's disease of bone. Laurier E, et al. BMC Med Genet, 2017 Nov 16. PMID 29145829, Free PMC Article
  3. Downregulation of TM7SF4 inhibits cell proliferation and metastasis of A549 cells through regulating the PI3K/AKT/mTOR signaling pathway. Yang X, et al. Mol Med Rep, 2017 Nov. PMID 28849122
  4. Transmembrane 7 superfamily member 4 regulates cell cycle progression in breast cancer cells. Zeng XX, et al. Eur Rev Med Pharmacol Sci, 2015 Nov. PMID 26636523
  5. Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene. Hartgers FC, et al. Immunogenetics, 2001 Mar. PMID 11345591

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer.
    Title: Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer.
  2. Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget's disease of bone.
    Title: Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget's disease of bone.
  3. TM7SF4 may be involved in the progression of lung cancer.
    Title: Downregulation of TM7SF4 inhibits cell proliferation and metastasis of A549 cells through regulating the PI3K/AKT/mTOR signaling pathway.
  4. Our results suggest that the rare genetic variant of TM7SF4 gene, found in our French-Canadian cohort of patients with Paget's disease of bone and which encodes the DC-STAMP protein, increase the number of nuclei per multinucleated cells and affect DC-STAMP expression during osteoclastogenesis in Paget's disease of bone.
    Title: Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget's disease of bone.
  5. TM7SF4 plays an essential role in regulating cell cycle progression in breast cancer.
    Title: Transmembrane 7 superfamily member 4 regulates cell cycle progression in breast cancer cells.
  6. The EP in TKA differed from EP in aseptically failed THA by lower CCL3 and DC-STAMP mRNA and protein expression. EP of all studied inflammatory and osteoclastogenic molecules were similar in knee and hip OA.
    Title: Comparison of periprosthetic tissues in knee and hip joints: differential expression of CCL3 and DC-STAMP in total knee and hip arthroplasty and similar cytokine profiles in primary knee and hip osteoarthritis.
  7. Our findings also suggest that next generation sequencing may help explore the pathogenesis and aid the diagnosis of Juvenile Paget's disease.
    Title: Polymorphisms of CSF1 and TM7SF4 genes in a case of mild juvenile Paget's disease found using next-generation sequencing.
  8. Rs62620995 in the TM7SF4 gene was found to have a marginal association with Paget's disease of bone in the French-Canadian population.
    Title: Identification of rare genetic variants in novel loci associated with Paget's disease of bone.
  9. DC-STAMP inhibition by RNA interference consequently suppressed fusion and bone resorption of human osteoclasts.
    Title: Lentivirus-mediated RNA interference of DC-STAMP expression inhibits the fusion and resorptive activity of human osteoclasts.
  10. An interaction between OS9 and DC-STAMP was confirmed by yeast-2-hybrid analysis and cellular colocalization.ER-to-Golgi translocation of DC-STAMP following TLR stimulation in CHO cells was demonstrated, involving the DC-STAMP/OS9 interaction. The data indicate that OS9 is critically involved in ER-to-Golgi transport of DC-STAMP, and may be important in both myeloid differentiation and cell fusion.
    Title: OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC138223, MGC138225, MGC177336

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to macrophage colony-stimulating factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoclast fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of macrophage fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of monocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dendritic cell-specific transmembrane protein
Names
DC-specific transmembrane protein
Dendritic cells (DC)-specific transmembrane protein
IL-4-induced protein
IL-Four (IL-4) induced
IL-Four INDuced
IL-four-induced protein
transmembrane 7 superfamily member 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257317.1 → NP_001244246.1  dendritic cell-specific transmembrane protein isoform 2

    See identical proteins and their annotated locations for NP_001244246.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region and uses an alternate splice site which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF277290, AP003471, BC171732, DA154308
    Consensus CDS
    CCDS59111.1
    UniProtKB/Swiss-Prot
    Q9H295
    Related
    ENSP00000480546.1, ENST00000622554.1
    Conserved Domains (1) summary
    pfam07782
    Location:242 → 278
    DC_STAMP; DC-STAMP-like protein

  2. NM_030788.4 → NP_110415.1  dendritic cell-specific transmembrane protein isoform 1

    See identical proteins and their annotated locations for NP_110415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF277290, AP003471, BC069349
    Consensus CDS
    CCDS6301.1
    UniProtKB/Swiss-Prot
    B7ZVW2, E7ESG0, Q2M2D5, Q9H295
    UniProtKB/TrEMBL
    B3KTD8
    Related
    ENSP00000297581.2, ENST00000297581.2
    Conserved Domains (1) summary
    pfam07782
    Location:242 → 421
    DC_STAMP; DC-STAMP-like protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    104339796..104356689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447288.2 → XP_024303056.1  dendritic cell-specific transmembrane protein isoform X1

    UniProtKB/Swiss-Prot
    B7ZVW2, E7ESG0, Q2M2D5, Q9H295
    UniProtKB/TrEMBL
    B3KTD8
    Conserved Domains (1) summary
    pfam07782
    Location:242 → 421
    DC_STAMP; DC-STAMP-like protein

  2. XM_024447289.2 → XP_024303057.1  dendritic cell-specific transmembrane protein isoform X2

    Conserved Domains (1) summary
    pfam07782
    Location:242 → 356
    DC_STAMP; DC-STAMP-like protein

  3. XM_047422277.1 → XP_047278233.1  dendritic cell-specific transmembrane protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    105466609..105484210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361300.1 → XP_054217275.1  dendritic cell-specific transmembrane protein isoform X1

    UniProtKB/Swiss-Prot
    B7ZVW2, E7ESG0, Q2M2D5, Q9H295

  2. XM_054361304.1 → XP_054217279.1  dendritic cell-specific transmembrane protein isoform X3

  3. XM_054361299.1 → XP_054217274.1  dendritic cell-specific transmembrane protein isoform X1

    UniProtKB/Swiss-Prot
    B7ZVW2, E7ESG0, Q2M2D5, Q9H295

  4. XM_054361302.1 → XP_054217277.1  dendritic cell-specific transmembrane protein isoform X2

  5. XM_054361303.1 → XP_054217278.1  dendritic cell-specific transmembrane protein isoform X2

  6. XM_054361301.1 → XP_054217276.1  dendritic cell-specific transmembrane protein isoform X1

    UniProtKB/Swiss-Prot
    B7ZVW2, E7ESG0, Q2M2D5, Q9H295
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H295.1 GenPept UniProtKB/Swiss-Prot:Q9H295

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous