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GPR63 G protein-coupled receptor 63 [ Homo sapiens (human) ]

Gene ID: 81491, updated on 23-Nov-2021

Summary

Official Symbol
GPR63provided by HGNC
Official Full Name
G protein-coupled receptor 63provided by HGNC
Primary source
HGNC:HGNC:13302
See related
Ensembl:ENSG00000112218 MIM:606915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSP24B; PSP24(beta)
Summary
This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Expression
Broad expression in testis (RPKM 1.6), brain (RPKM 1.0) and 21 other tissues See more
Orthologs
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Genomic context

See GPR63 in Genome Data Viewer
Location:
6q16.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (96794125..96837477, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (97242001..97285353, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377908 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 6 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 Neighboring gene RNA, 7SL, cytoplasmic 509, pseudogene Neighboring gene kelch like family member 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 63
Names
PSP24-2
PSP24-beta
brain expressed G-protein-coupled receptor PSP24 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143957.3NP_001137429.1  probable G-protein coupled receptor 63

    See identical proteins and their annotated locations for NP_001137429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AI208851, AK289839, AK313535, AL033379, DA242987, DB119067
    Consensus CDS
    CCDS5036.1
    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_030784.4NP_110411.1  probable G-protein coupled receptor 63

    See identical proteins and their annotated locations for NP_110411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AI208851, AK289839, AK313535, AL033379, DA242987
    Consensus CDS
    CCDS5036.1
    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Related
    ENSP00000229955.2, ENST00000229955.4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    96794125..96837477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536155.2XP_011534457.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534457.1

    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011536159.2XP_011534461.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534461.1

    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011536157.2XP_011534459.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534459.1

    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011536154.2XP_011534456.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534456.1

    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_011536153.2XP_011534455.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534455.1

    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_017011334.1XP_016866823.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. XM_006715570.4XP_006715633.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_006715633.1

    UniProtKB/Swiss-Prot
    Q9BZJ6
    UniProtKB/TrEMBL
    A8K1C4
    Conserved Domains (1) summary
    cd15404
    Location:82382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
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