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OR2AE1 olfactory receptor family 2 subfamily AE member 1 [ Homo sapiens (human) ]

Gene ID: 81392, updated on 25-Nov-2021

Summary

Official Symbol
OR2AE1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily AE member 1provided by HGNC
Primary source
HGNC:HGNC:15087
See related
Ensembl:ENSG00000244623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2AE2
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR2AE1 in Genome Data Viewer
Location:
7q22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99876062..99877033, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99473685..99474656, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 3 subfamily A member 43 Neighboring gene cytochrome P450 family 3 subfamily A member 52, pseudogene Neighboring gene tripartite motif containing 4 Neighboring gene uncharacterized LOC101927610 Neighboring gene gap junction protein gamma 3

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 2AE1
Names
olfactory receptor 2AE2
olfactory receptor, family 2, subfamily AE, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005276.1NP_001005276.1  olfactory receptor 2AE1

    See identical proteins and their annotated locations for NP_001005276.1

    Status: VALIDATED

    Source sequence(s)
    AB065478
    Consensus CDS
    CCDS34696.1
    UniProtKB/Swiss-Prot
    Q8NHA4
    Related
    ENSP00000313936.2, ENST00000316368.3
    Conserved Domains (1) summary
    cd15421
    Location:25300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99876062..99877033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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