PF3D7_1343000 phosphoethanolamine N-methyltransferase [Plasmodium falciparum 3D7] - Gene

Summary

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Gene symbol: PF3D7_1343000
Gene description: phosphoethanolamine N-methyltransferase
Locus tag: PF3D7_1343000
See related: PlasmoDB:PF3D7_1343000; VEuPathDB:PF3D7_1343000
Gene type: protein coding
RNA name: phosphoethanolamine N-methyltransferase
RefSeq status: PROVISIONAL
Organism: Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage: Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs: all
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Genomic context

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See PF3D7_1343000 in Genome Data Viewer

Location:: chromosome: 13

Exon count:: 4

Sequence:: Chromosome: 13; NC_004331.3 (1696894..1698113)

Chromosome 13 - NC_004331.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasmodium falciparum phosphoethanolamine methyltransferase catalyzes the phosphoethanolamine methylation via an alternative mechanism.
Title: An alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase.
Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.
Title: Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.
Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects.
Title: Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects.
Mutations in residues Asp-61, Gly-83 and Asp-128 dramatically altered PfPMT activity and its complementation of the yeast mutant.
Title: Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum.
Phosphoethanolamine methyltransferase, Pfpmt, a critical enzyme in the SDPM pathway, is down-regulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline.
Title: Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase.
Pfpmt activity is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine
Title: In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway.
the transmethylation step of the SDPM pathway of P. falciparum occurs in the Golgi apparatus
Title: Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by GeneDB

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables phosphoethanolamine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphatidylcholine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular vesicle	HDA more info	PubMed
located_in food vacuole	HDA more info	PubMed