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OR4P4 olfactory receptor family 4 subfamily P member 4 [ Homo sapiens (human) ]

Gene ID: 81300, updated on 2-Nov-2024

Summary

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Official Symbol
OR4P4provided by HGNC
Official Full Name
olfactory receptor family 4 subfamily P member 4provided by HGNC
Primary source
HGNC:HGNC:15180
See related
Ensembl:ENSG00000181927 AllianceGenome:HGNC:15180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR4P3P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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See OR4P4 in Genome Data Viewer
Location:
11q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (55635113..55640309)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (55573394..55578590)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (55402589..55407785)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily C member 16 Neighboring gene olfactory receptor family 4 subfamily C member 11 Neighboring gene olfactory receptor family 4 subfamily S member 2 Neighboring gene olfactory receptor family 4 subfamily C member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 4P4
Names
olfactory receptor 4P3
olfactory receptor, family 4, subfamily P, member 3 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004124.2 → NP_001004124.1  olfactory receptor 4P4 isoform 1

    See identical proteins and their annotated locations for NP_001004124.1

    Status: VALIDATED

    Source sequence(s)
    AP006437
    Consensus CDS
    CCDS31504.1
    UniProtKB/Swiss-Prot
    Q8NGL7
    UniProtKB/TrEMBL
    A0A126GVX4
    Conserved Domains (2) summary
    pfam00001
    Location:39 → 285
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:29 → 301
    7tm_4; Olfactory receptor

  2. NM_001405919.1 → NP_001392848.1  olfactory receptor 4P4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP006437
    UniProtKB/Swiss-Prot
    Q8NGL7
    Related
    ENSP00000493384.1, ENST00000641760.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    55635113..55640309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    55573394..55578590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGL7.1 GenPept UniProtKB/Swiss-Prot:Q8NGL7

Gene LinkOut

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