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PF3D7_0509800 phosphatidylinositol 4-kinase [ Plasmodium falciparum 3D7 ]

Gene ID: 812838, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_0509800
Gene description
phosphatidylinositol 4-kinase
Locus tag
PF3D7_0509800
See related
PlasmoDB:PF3D7_0509800; VEuPathDB:PF3D7_0509800
Gene type
protein coding
RNA name
phosphatidylinositol 4-kinase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_0509800 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Sequence:
Chromosome: 5; NC_004326.2 (410268..415308)

Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene asparagine--tRNA ligase Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004326.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Paquet T, et al. Sci Transl Med, 2017 Apr 26. PMID 28446690, Free PMC Article
  2. Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4-Kinase IIIβ. Sternberg AR, et al. Biochemistry, 2020 Jul 14. PMID 32543181
  3. Targeting Plasmodium PI(4)K to eliminate malaria. McNamara CW, et al. Nature, 2013 Dec 12. PMID 24284631, Free PMC Article
  4. Complementation of Saccharomyces cerevisiaepik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum. Krüger T, et al. Mol Biochem Parasitol, 2010 Aug. PMID 20381540
  5. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data show that Plasmodium falciparum PFE0485w can functionally complement a Saccharomyces cerevisiae temperature-sensitive pik1 mutation.
    Title: Complementation of Saccharomyces cerevisiaepik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol 4-kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol metabolic process ISM
Inferred from Sequence Model
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-kinase
XP_001351656.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004326.2 Reference assembly

    Range
    410268..415308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351620.1 → XP_001351656.1  phosphatidylinositol 4-kinase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351656.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0L7LWD8, A0A2I0BUP8, Q8I406
    Conserved Domains (2) summary
    cd05168
    Location:1273 → 1559
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cl00271
    Location:375 → 488
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
Nucleotide Protein
Heading Accession and Version

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