TCL1A TCL1 family AKT coactivator A [Homo sapiens (human)] - Gene

Summary

Official Symbol: TCL1Aprovided by HGNC
Official Full Name: TCL1 family AKT coactivator Aprovided by HGNC
Primary source: HGNC:HGNC:11648
See related: Ensembl:ENSG00000100721 MIM:186960; AllianceGenome:HGNC:11648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TCL1
Summary: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Expression: Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues See more
Orthologs: all
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Genomic context

Location:: 14q32.13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (95709947..95714125, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (89941532..89945710, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (96176284..96180462, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.
Title: TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.
Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.
Title: Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.
Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
Title: Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
TCL1A also acts as a transcriptional coregulator with NF-kappaB p65
Title: TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence.
TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.
Title: TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.
Combination of T-cell lymphoma-1 protein (TCL1)-overexpression and damaging ataxia telangiectasia mutated protein (ATM) functionally synergistically contribute to T-cell prolymphocytic leukemia (T-PLL) specific phenotype of impaired DNA damage processing.
Title: Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
Case Report: hematogones can express TCL-1 in patients with T-cell prolymphocytic leukemia after therapy.
Title: TCL-1-positive hematogones in a patient with T-cell prolymphocytic leukemia after therapy.
TCL1A is not only a useful biomarker for prognostic evaluation in stage II/III colorectal cancer patients.
Title: T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer.
Our results suggest that intratumoral TCL1A+ B cells are important for controlling cervical cancer development.
Title: Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival.
Our study suggests that TCL1 expression profile may have a role in the prediction of overall outcome in patient with MCL and call for prospective studies.
Title: TCL1 expression predicts overall survival in patients with mantle cell lymphoma.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-153944 (e-PCR)
- UniSTS:182803

TCL1A_1080 (e-PCR)
- UniSTS:277797

RH44550 (e-PCR)
- UniSTS:70020

SGC35414 (e-PCR)
- UniSTS:69034

GDB:593221 (e-PCR)
- UniSTS:157943

SHGC-142631 (e-PCR)
- UniSTS:182782

Homology

Homologs of the TCL1A gene: The TCL1A gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 154 organisms have orthologs with human gene TCL1A
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitochondrial membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: T-cell leukemia/lymphoma protein 1A

Names: T cell leukemia/lymphoma 1A; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098725.2 → NP_001092195.1 T-cell leukemia/lymphoma protein 1A

See identical proteins and their annotated locations for NP_001092195.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL139020, BC014024, BG718395, X82240

Consensus CDS

CCDS9941.1

UniProtKB/Swiss-Prot

P56279, Q6IBK7

UniProtKB/TrEMBL

A0A024R6G5

Related

ENSP00000451506.1, ENST00000554012.5

Conserved Domains (1) summary

pfam01840
Location:1 → 112

TCL1_MTCP1; TCL1/MTCP1 family
NM_021966.3 → NP_068801.1 T-cell leukemia/lymphoma protein 1A

See identical proteins and their annotated locations for NP_068801.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AL139020, BC014024, BG718395, X82240

Consensus CDS

CCDS9941.1

UniProtKB/Swiss-Prot

P56279, Q6IBK7

UniProtKB/TrEMBL

A0A024R6G5

Related

ENSP00000385036.1, ENST00000402399.6

Conserved Domains (1) summary

pfam01840
Location:1 → 112

TCL1_MTCP1; TCL1/MTCP1 family

RNA

NR_049726.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL139020, BU602054, X82240