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TCL1A T cell leukemia/lymphoma 1A [ Homo sapiens (human) ]

Gene ID: 8115, updated on 9-Dec-2018

Summary

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Official Symbol
TCL1Aprovided by HGNC
Official Full Name
T cell leukemia/lymphoma 1Aprovided by HGNC
Primary source
HGNC:HGNC:11648
See related
Ensembl:ENSG00000100721 MIM:186960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCL1
Summary
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Expression
Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues See more
Orthologs
all

Genomic context

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See TCL1A in Genome Data Viewer
Location:
14q32.13
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (95694160..95714196, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96176304..96180533, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene T cell leukemia/lymphoma 6 Neighboring gene T cell leukemia/lymphoma 1B Neighboring gene uncharacterized LOC107984703 Neighboring gene uncharacterized LOC105370644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TCL-1-positive hematogones in a patient with T-cell prolymphocytic leukemia after therapy. Hu Z, et al. Hum Pathol, 2017 Jul. PMID 28232160
  2. T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer. Li H, et al. Biomed Pharmacother, 2017 Apr. PMID 28178623
  3. TCL1 expression patterns in Waldenström macroglobulinemia. Lemal R, et al. Mod Pathol, 2016 Jan. PMID 26493619
  4. Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival. Punt S, et al. Oncotarget, 2015 Nov 17. PMID 26299617, Free PMC Article
  5. TCL1 expression predicts overall survival in patients with mantle cell lymphoma. Shin SJ, et al. Eur J Haematol, 2015 Dec. PMID 25688912

See all (84) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. Combination of T-cell lymphoma-1 protein (TCL1)-overexpression and damaging ataxia telangiectasia mutated protein (ATM) functionally synergistically contribute to T-cell prolymphocytic leukemia (T-PLL) specific phenotype of impaired DNA damage processing.
    Title: Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.
  2. Case Report: hematogones can express TCL-1 in patients with T-cell prolymphocytic leukemia after therapy.
    Title: TCL-1-positive hematogones in a patient with T-cell prolymphocytic leukemia after therapy.
  3. TCL1A is not only a useful biomarker for prognostic evaluation in stage II/III colorectal cancer patients.
    Title: T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer.
  4. Our results suggest that intratumoral TCL1A+ B cells are important for controlling cervical cancer development.
    Title: Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival.
  5. Our study suggests that TCL1 expression profile may have a role in the prediction of overall outcome in patient with MCL and call for prospective studies.
    Title: TCL1 expression predicts overall survival in patients with mantle cell lymphoma.
  6. We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenstrom macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact.
    Title: TCL1 expression patterns in Waldenström macroglobulinemia.
  7. Suggest miR-181b as therapeutic target for chronic lymphocytic leukemia in the Emicro-TCL1 mouse model.
    Title: miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eµ-TCL1 mouse model.
  8. High TCL1A expression is associated with chronic lymphocytic leukemia.
    Title: The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL.
  9. Polymorphic genetic variations of cytochrome P450 19A1 and T-cell leukemia 1A genes in the Tamil population
    Title: Polymorphic genetic variations of cytochrome P450 19A1 and T-cell leukemia 1A genes in the Tamil population.
  10. Peptide-based TCL1-interphase mimics were potent in steric AKT antagonization.
    Title: AKT-pathway inhibition in chronic lymphocytic leukemia reveals response relationships defined by TCL1.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from BioSystems

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  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
 PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
 PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of protein oligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
nucleus IEA
Inferred from Electronic Annotation
more info
  
protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
T-cell leukemia/lymphoma protein 1A
Names
T-cell lymphoma-1
oncogene TCL-1
oncogene TCL1
protein p14 TCL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098725.1 → NP_001092195.1  T-cell leukemia/lymphoma protein 1A

    See identical proteins and their annotated locations for NP_001092195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL139020, BC014024, BG718395, X82240
    Consensus CDS
    CCDS9941.1
    UniProtKB/Swiss-Prot
    P56279
    UniProtKB/TrEMBL
    A0A024R6G5
    Related
    ENSP00000451506.1, ENST00000554012.5
    Conserved Domains (1) summary
    pfam01840
    Location:1 → 112
    TCL1_MTCP1; TCL1/MTCP1 family

  2. NM_021966.3 → NP_068801.1  T-cell leukemia/lymphoma protein 1A

    See identical proteins and their annotated locations for NP_068801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AL139020, BC014024, BG718395, X82240
    Consensus CDS
    CCDS9941.1
    UniProtKB/Swiss-Prot
    P56279
    UniProtKB/TrEMBL
    A0A024R6G5
    Related
    ENSP00000385036.1, ENST00000402399.5
    Conserved Domains (1) summary
    pfam01840
    Location:1 → 112
    TCL1_MTCP1; TCL1/MTCP1 family

RNA

  1. NR_049726.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL139020, BG718395, BU602054, X82240

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    95694160..95714196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021676.2 → XP_016877165.1  T-cell leukemia/lymphoma protein 1A isoform X1

    UniProtKB/Swiss-Prot
    P56279
    UniProtKB/TrEMBL
    A0A024R6G5
    Conserved Domains (1) summary
    pfam01840
    Location:1 → 112
    TCL1_MTCP1; TCL1/MTCP1 family

  2. XM_017021677.2 → XP_016877166.1  T-cell leukemia/lymphoma protein 1A isoform X1

    UniProtKB/Swiss-Prot
    P56279
    UniProtKB/TrEMBL
    A0A024R6G5
    Related
    ENSP00000450496.1, ENST00000555202.1
    Conserved Domains (1) summary
    pfam01840
    Location:1 → 112
    TCL1_MTCP1; TCL1/MTCP1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56279.1 GenPept UniProtKB/Swiss-Prot:P56279

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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