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SLC2A10 solute carrier family 2 member 10 [ Homo sapiens (human) ]

Gene ID: 81031, updated on 28-Nov-2020

Summary

Official Symbol
SLC2A10provided by HGNC
Official Full Name
solute carrier family 2 member 10provided by HGNC
Primary source
HGNC:HGNC:13444
See related
Ensembl:ENSG00000197496 MIM:606145
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATS; ATORS; GLUT10
Summary
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]
Expression
Broad expression in prostate (RPKM 8.3), thyroid (RPKM 6.7) and 24 other tissues See more
Orthologs

Genomic context

See SLC2A10 in Genome Data Viewer
Location:
20q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (46708358..46736347)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45338279..45364986)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 member 3 Neighboring gene TP53 regulating kinase Neighboring gene RN7SK pseudogene 33 Neighboring gene ribosomal protein L13 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126706

Gene Ontology Provided by GOA

Process Evidence Code Pubs
artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
embryonic skeletal joint development IMP
Inferred from Mutant Phenotype
more info
PubMed 
galactose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
glucose import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
glucose transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
hexose transmembrane transport TAS
Traceable Author Statement
more info
 
negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of connective tissue growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 10
Names
GLUT-10
glucose transporter type 10
solute carrier family 2 (facilitated glucose transporter), member 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016284.1 RefSeqGene

    Range
    5010..31708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030777.4NP_110404.1  solute carrier family 2, facilitated glucose transporter member 10

    See identical proteins and their annotated locations for NP_110404.1

    Status: REVIEWED

    Source sequence(s)
    AF248053, AF321240
    Consensus CDS
    CCDS13402.1
    UniProtKB/Swiss-Prot
    O95528
    Related
    ENSP00000352216.2, ENST00000359271.4
    Conserved Domains (1) summary
    cl26863
    Location:11512
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    46708358..46736347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529064.2XP_011527366.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X5

    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:37344
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
  2. XM_011529062.2XP_011527364.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X3

    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:37344
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
  3. XM_011529063.2XP_011527365.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X4

    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32500
    Sugar_tr; Sugar (and other) transporter
  4. XM_011529065.2XP_011527367.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X6

    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32493
    Sugar_tr; Sugar (and other) transporter
  5. XM_011529060.2XP_011527362.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

    See identical proteins and their annotated locations for XP_011527362.1

    Conserved Domains (2) summary
    cd06174
    Location:35518
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32533
    Sugar_tr; Sugar (and other) transporter
  6. XM_017028087.2XP_016883576.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X7

  7. XM_011529061.2XP_011527363.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:17500
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:14515
    Sugar_tr; Sugar (and other) transporter

RNA

  1. XR_936641.2 RNA Sequence

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