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SLC2A10 solute carrier family 2 member 10 [ Homo sapiens (human) ]

Gene ID: 81031, updated on 29-Mar-2023

Summary

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Official Symbol
SLC2A10provided by HGNC
Official Full Name
solute carrier family 2 member 10provided by HGNC
Primary source
HGNC:HGNC:13444
See related
Ensembl:ENSG00000197496 MIM:606145; AllianceGenome:HGNC:13444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATS; ATORS; GLUT10
Summary
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]
Expression
Broad expression in prostate (RPKM 8.3), thyroid (RPKM 6.7) and 24 other tissues See more
Orthologs
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Genomic context

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See SLC2A10 in Genome Data Viewer
Location:
20q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46708320..46736347)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (48444561..48472618)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45338288..45364986)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 13 member 3 Neighboring gene TP53 regulating kinase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45331499-45332271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354240-45354740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354741-45355241 Neighboring gene uncharacterized LOC124904918 Neighboring gene uncharacterized LOC124904919

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. H22954, a long non-coding RNA, inhibits glucose uptake in leukemia cells in a GLUT10-dependent manner. Bai Y, et al. Hematology, 2022 Dec. PMID 35413230
  2. Arterial Tortuosity Syndrome: An Ascorbate Compartmentalization Disorder? Boel A, et al. Antioxid Redox Signal, 2021 Apr 10. PMID 31621376
  3. Arterial tortuosity syndrome: 40 new families and literature review. Beyens A, et al. Genet Med, 2018 Oct. PMID 29323665
  4. Ophthalmic findings in patients with arterial tortuosity syndrome and carriers: A case series. Hardin JS, et al. Ophthalmic Genet, 2018 Jan-Feb. PMID 28726533
  5. Arterial Tortuosity Syndrome. Adam MP, et al. , 1993. PMID 25392904

See all (41) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. H22954, a long non-coding RNA, inhibits glucose uptake in leukemia cells in a GLUT10-dependent manner.
    Title: H22954, a long non-coding RNA, inhibits glucose uptake in leukemia cells in a GLUT10-dependent manner.
  2. Arterial Tortuosity Syndrome: An Ascorbate Compartmentalization Disorder?
    Title: Arterial Tortuosity Syndrome: An Ascorbate Compartmentalization Disorder?
  3. Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects.
    Title: Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects.
  4. The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia.
    Title: The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia.
  5. Data show that GLUT10 regulates adipogenesis via ascorbic acid-dependent DNA demethylation to benefit proper white adipose tissue development and protect mice against high-fat diet (HFD)-induced metabolic dysregulation. These findings suggest that SLC2A10 may be an important HFD-associated susceptibility locus for type 2 diabetes mellitus.
    Title: Glucose transporter 10 modulates adipogenesis via an ascorbic acid-mediated pathway to protect mice against diet-induced metabolic dysregulation.
  6. We delineate the clinical spectrum and describe the histology in arterial tortuosity syndrome (ATS), a rare connective tissue disorder characterized by tortuosity of the large and medium-sized arteries, caused by mutations in SLC2A10
    Title: Arterial tortuosity syndrome: 40 new families and literature review.
  7. We document a spectrum of ophthalmic manifestations of arterial tortuosity syndrome with universal findings of myopia, corneal thinning, and a propensity for corneal ectasia leading to keratoconus or keratoglobus. Heterozygous carriers may develop keratectasia after corneal refractive surgery
    Title: Ophthalmic findings in patients with arterial tortuosity syndrome and carriers: A case series.
  8. GLUT10 is a dehydroascorbic acid (DAA) transporter and DAA transport is diminished in the endomembranes of fibroblasts from Arterial Tortuosity syndrome patients.
    Title: Glucose transporter type 10-lacking in arterial tortuosity syndrome-facilitates dehydroascorbic acid transport.
  9. GLUT10 deficiency leads to oxidative stress and non-canonical alphavbeta3 integrin-mediated TGFbeta signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts
    Title: GLUT10 deficiency leads to oxidative stress and non-canonical αvβ3 integrin-mediated TGFβ signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts.
  10. 100 ATS patients have been described, and 21 causal mutations have been identified in the SLC2A10 gene. Study expanded the allelic repertoire of SLC2A10 by identifying two novel mutations.
    Title: Arterial Tortuosity Syndrome: homozygosity for two novel and one recurrent SLC2A10 missense mutations in three families with severe cardiopulmonary complications in infancy and a literature review.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Arterial tortuosity syndrome
MedGen: C1859726 OMIM: 208050 GeneReviews: Arterial Tortuosity Syndrome
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126706

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables carbohydrate:proton symporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables dehydroascorbic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within artery development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circulatory system development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal joint development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in glucose import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in glucose transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
  
acts_upstream_of_or_within negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of connective tissue growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 10
Names
GLUT-10
facilitative glucose transporter GLUT10
glucose transporter type 10
solute carrier family 2 (facilitated glucose transporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016284.1 RefSeqGene

    Range
    5010..31708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030777.4 → NP_110404.1  solute carrier family 2, facilitated glucose transporter member 10

    See identical proteins and their annotated locations for NP_110404.1

    Status: REVIEWED

    Source sequence(s)
    AF248053, AF321240
    Consensus CDS
    CCDS13402.1
    UniProtKB/Swiss-Prot
    O95528, Q9H4I6
    Related
    ENSP00000352216.2, ENST00000359271.4
    Conserved Domains (1) summary
    cl26863
    Location:11 → 512
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    46708320..46736347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529062.3 → XP_011527364.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X4

    Conserved Domains (2) summary
    cd06174
    Location:35 → 351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:37 → 344
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

  2. XM_011529060.3 → XP_011527362.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

    See identical proteins and their annotated locations for XP_011527362.1

    Conserved Domains (2) summary
    cd06174
    Location:35 → 518
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32 → 533
    Sugar_tr; Sugar (and other) transporter

  3. XM_011529065.3 → XP_011527367.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X8

    Conserved Domains (2) summary
    cd06174
    Location:35 → 351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32 → 493
    Sugar_tr; Sugar (and other) transporter

  4. XM_047440528.1 → XP_047296484.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X3

  5. XM_011529063.3 → XP_011527365.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X5

    Conserved Domains (2) summary
    cd06174
    Location:35 → 351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32 → 500
    Sugar_tr; Sugar (and other) transporter

  6. XM_011529064.3 → XP_011527366.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X7

    Conserved Domains (2) summary
    cd06174
    Location:35 → 351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:37 → 344
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

  7. XM_011529061.3 → XP_011527363.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:17 → 500
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:14 → 515
    Sugar_tr; Sugar (and other) transporter

  8. XM_047440529.1 → XP_047296485.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X6

  9. XM_017028087.3 → XP_016883576.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    48444561..48472618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324094.1 → XP_054180069.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X8

  2. XM_054324087.1 → XP_054180062.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

  3. XM_054324090.1 → XP_054180065.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X4

  4. XM_054324089.1 → XP_054180064.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X3

  5. XM_054324091.1 → XP_054180066.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X10

  6. XM_054324093.1 → XP_054180068.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X7

  7. XM_054324088.1 → XP_054180063.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X2

  8. XM_054324092.1 → XP_054180067.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X6

  9. XM_054324095.1 → XP_054180070.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95528.2 GenPept UniProtKB/Swiss-Prot:O95528

Gene LinkOut

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