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SLC2A10 solute carrier family 2 member 10 [ Homo sapiens (human) ]

Gene ID: 81031, updated on 18-Sep-2024

Summary

Official Symbol
SLC2A10provided by HGNC
Official Full Name
solute carrier family 2 member 10provided by HGNC
Primary source
HGNC:HGNC:13444
See related
Ensembl:ENSG00000197496 MIM:606145; AllianceGenome:HGNC:13444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATS; ATORS; GLUT10
Summary
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]
Expression
Broad expression in prostate (RPKM 8.3), thyroid (RPKM 6.7) and 24 other tissues See more
Orthologs
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Genomic context

See SLC2A10 in Genome Data Viewer
Location:
20q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46708320..46736347)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (48444561..48472618)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45338288..45364986)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45197011-45197512 Neighboring gene solute carrier family 13 member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45211603-45212425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45212426-45213247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17977 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:45250755-45251328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45259736-45260484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45260485-45261231 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45302100-45302256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45303169-45303683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45311939-45312450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17979 Neighboring gene TP53RK divergent transcript Neighboring gene TP53 regulating kinase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45331499-45332271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354240-45354740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354741-45355241 Neighboring gene uncharacterized LOC124904918 Neighboring gene uncharacterized LOC124904919

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126706

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in D-glucose import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in D-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in D-glucose transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circulatory system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal joint development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in galactose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within negative regulation of connective tissue growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 10
Names
GLUT-10
facilitative glucose transporter GLUT10
glucose transporter type 10
solute carrier family 2 (facilitated glucose transporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016284.1 RefSeqGene

    Range
    5010..31708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030777.4NP_110404.1  solute carrier family 2, facilitated glucose transporter member 10

    See identical proteins and their annotated locations for NP_110404.1

    Status: REVIEWED

    Source sequence(s)
    AF248053, AF321240
    Consensus CDS
    CCDS13402.1
    UniProtKB/Swiss-Prot
    A8K4J6, O95528, Q3MIX5, Q9H4I6
    UniProtKB/TrEMBL
    B2RCT7, B3KP22
    Related
    ENSP00000352216.2, ENST00000359271.4
    Conserved Domains (1) summary
    cl26863
    Location:11512
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    46708320..46736347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529062.3XP_011527364.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X4

    UniProtKB/TrEMBL
    B2RCT7
    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:37344
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
  2. XM_011529060.3XP_011527362.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

    See identical proteins and their annotated locations for XP_011527362.1

    UniProtKB/TrEMBL
    B2RCT7, B3KP22
    Conserved Domains (2) summary
    cd06174
    Location:35518
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32533
    Sugar_tr; Sugar (and other) transporter
  3. XM_011529065.3XP_011527367.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X8

    UniProtKB/TrEMBL
    B2RCT7
    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32493
    Sugar_tr; Sugar (and other) transporter
  4. XM_047440528.1XP_047296484.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X3

  5. XM_011529063.3XP_011527365.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X5

    UniProtKB/TrEMBL
    B2RCT7
    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:32500
    Sugar_tr; Sugar (and other) transporter
  6. XM_011529064.3XP_011527366.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X7

    Conserved Domains (2) summary
    cd06174
    Location:35351
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:37344
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
  7. XM_011529061.3XP_011527363.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X2

    UniProtKB/TrEMBL
    B2RCT7, B3KP22
    Conserved Domains (2) summary
    cd06174
    Location:17500
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:14515
    Sugar_tr; Sugar (and other) transporter
  8. XM_047440529.1XP_047296485.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X6

    UniProtKB/TrEMBL
    B2RCT7
  9. XM_017028087.3XP_016883576.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X9

    UniProtKB/TrEMBL
    B2RCT7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    48444561..48472618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324094.1XP_054180069.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X8

    UniProtKB/TrEMBL
    B2RCT7
  2. XM_054324087.1XP_054180062.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

    UniProtKB/TrEMBL
    B2RCT7, B3KP22
  3. XM_054324090.1XP_054180065.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X4

    UniProtKB/TrEMBL
    B2RCT7
  4. XM_054324089.1XP_054180064.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X3

  5. XM_054324091.1XP_054180066.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X10

    UniProtKB/TrEMBL
    B2RCT7
  6. XM_054324093.1XP_054180068.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X7

  7. XM_054324088.1XP_054180063.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X2

    UniProtKB/TrEMBL
    B2RCT7, B3KP22
  8. XM_054324092.1XP_054180067.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X6

    UniProtKB/TrEMBL
    B2RCT7
  9. XM_054324095.1XP_054180070.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X9

    UniProtKB/TrEMBL
    B2RCT7