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Tbl1xr1 transducin (beta)-like 1X-linked receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 81004, updated on 5-Jan-2023

Summary

Official Symbol
Tbl1xr1provided by MGI
Official Full Name
transducin (beta)-like 1X-linked receptor 1provided by MGI
Primary source
MGI:MGI:2441730
See related
Ensembl:ENSMUSG00000027630 AllianceGenome:MGI:2441730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C21; DC42; Ira1; TBLR1; 8030499H02Rik; A630076E03Rik; C230089I12Rik
Summary
Enables transcription cis-regulatory region binding activity and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blastocyst hatching; fat pad development; and white fat cell differentiation. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Is expressed in early conceptus; secondary oocyte; and thymus primordium. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 41. Orthologous to human TBL1XR1 (TBL1X receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 4.6), limb E14.5 (RPKM 4.3) and 28 other tissues See more
Orthologs
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Genomic context

See Tbl1xr1 in Genome Data Viewer
Location:
3; 3 A3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (22130756..22270758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (22076253..22216594)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 7530428D23 gene Neighboring gene predicted gene, 31813 Neighboring gene high mobility group box 1 pseudogene Neighboring gene ribonuclease P RNA-like 2 Neighboring gene predicted gene, 37636

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fat pad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
F-box-like/WD repeat-containing protein TBL1XR1
Names
F-box-like/WD repeat protein TBL1XR1
TBL1-related protein 1
nuclear receptor corepressor/HDAC3 complex subunit TBLR1
transducin beta-like 1X-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030732.3NP_109657.2  F-box-like/WD repeat-containing protein TBL1XR1

    See identical proteins and their annotated locations for NP_109657.2

    Status: VALIDATED

    Source sequence(s)
    AC121108, AC126599, AK033347
    Consensus CDS
    CCDS17266.1
    UniProtKB/Swiss-Prot
    Q8BHJ5, Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Related
    ENSMUSP00000144436.2, ENSMUST00000202747.4
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    22130756..22270758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249719.2XP_011248021.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    See identical proteins and their annotated locations for XP_011248021.1

    UniProtKB/Swiss-Prot
    Q8BHJ5, Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  2. XM_006535581.5XP_006535644.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X2

    Conserved Domains (3) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:172215
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
  3. XM_006535579.4XP_006535642.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    See identical proteins and their annotated locations for XP_006535642.1

    UniProtKB/Swiss-Prot
    Q8BHJ5, Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Related
    ENSMUSP00000142184.2, ENSMUST00000193734.6
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  4. XM_011249723.4XP_011248025.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X3

    See identical proteins and their annotated locations for XP_011248025.1

    Conserved Domains (3) summary
    cd00200
    Location:77383
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:141177
    7WD40; WD40 repeat [structural motif]
    cl29726
    Location:349427
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  5. XM_030252921.1XP_030108781.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X2

    Conserved Domains (3) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:172215
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
  6. XM_011249718.4XP_011248020.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    See identical proteins and their annotated locations for XP_011248020.1

    UniProtKB/Swiss-Prot
    Q8BHJ5, Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  7. XM_017319817.2XP_017175306.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHJ5, Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  8. XM_006535580.5XP_006535643.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    See identical proteins and their annotated locations for XP_006535643.1

    UniProtKB/Swiss-Prot
    Q8BHJ5, Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Related
    ENSMUSP00000067164.9, ENSMUST00000063988.14
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  9. XM_030252922.2XP_030108782.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X3

    Conserved Domains (3) summary
    cd00200
    Location:77383
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:141177
    7WD40; WD40 repeat [structural motif]
    cl29726
    Location:349427
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  10. XM_030252920.2XP_030108780.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  11. XM_011249721.4XP_011248023.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1

    See identical proteins and their annotated locations for XP_011248023.1

    UniProtKB/Swiss-Prot
    Q8BHJ5, Q9EQD4
    UniProtKB/TrEMBL
    A0A6P5PF03, A0A8C6GCW6
    Conserved Domains (4) summary
    cd00200
    Location:164470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:228264
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:731
    LisH
    cl29726
    Location:436514
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
  12. XM_011249724.4XP_011248026.1  F-box-like/WD repeat-containing protein TBL1XR1 isoform X3

    See identical proteins and their annotated locations for XP_011248026.1

    Conserved Domains (3) summary
    cd00200
    Location:77383
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:141177
    7WD40; WD40 repeat [structural motif]
    cl29726
    Location:349427
    TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]