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Castor2 cytosolic arginine sensor for mTORC1 subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 80909, updated on 5-Mar-2024

Summary

Official Symbol
Castor2provided by MGI
Official Full Name
cytosolic arginine sensor for mTORC1 subunit 2provided by MGI
Primary source
MGI:MGI:1933384
See related
Ensembl:ENSMUSG00000015944 AllianceGenome:MGI:1933384
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gats; Gatsl1; Gatsl2; 7530428J21Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol. Orthologous to several human genes including CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 8.6), frontal lobe adult (RPKM 7.4) and 24 other tissues See more
Orthologs
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Genomic context

See Castor2 in Genome Data Viewer
Location:
5 G2; 5 74.39 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134128587..134170621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134099748..134141782)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40339 Neighboring gene predicted gene, 40340 Neighboring gene predicted gene 15627 Neighboring gene reculator of chromosome condensation 1 like Neighboring gene STARR-positive B cell enhancer ABC_E3627 Neighboring gene STARR-positive B cell enhancer ABC_E105 Neighboring gene STARR-positive B cell enhancer ABC_E4791 Neighboring gene GTF2I repeat domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to L-arginine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic arginine sensor for mTORC1 subunit 2
Names
GATS protein-like 2
GATS-like protein 1
GATS-like protein 2
opposite strand transcription unit to Stag3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030719.3NP_109644.2  cytosolic arginine sensor for mTORC1 subunit 2

    See identical proteins and their annotated locations for NP_109644.2

    Status: PROVISIONAL

    Source sequence(s)
    BC094613
    Consensus CDS
    CCDS19717.1
    UniProtKB/Swiss-Prot
    Q8C7A9, Q8CAB8, Q9ER44
    Related
    ENSMUSP00000016088.9, ENSMUST00000016088.9
    Conserved Domains (1) summary
    pfam13840
    Location:262322
    ACT_7; ACT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134128587..134170621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)