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Hspb8 heat shock protein 8 [ Mus musculus (house mouse) ]

Gene ID: 80888, updated on 8-Feb-2024

Summary

Official Symbol
Hspb8provided by MGI
Official Full Name
heat shock protein 8provided by MGI
Primary source
MGI:MGI:2135756
See related
Ensembl:ENSMUSG00000041548 AllianceGenome:MGI:2135756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H11; H11K; Cryac; E2IG1; HSP22; D5Ucla4; HSP20-like
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein and positive regulation of aggrephagy. Predicted to be located in cytosol and nuclear body. Predicted to be part of chaperone complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study distal hereditary motor neuronopathy type 2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and distal hereditary motor neuronopathy type 2A. Orthologous to human HSPB8 (heat shock protein family B (small) member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 200.3), liver adult (RPKM 87.3) and 12 other tissues See more
Orthologs
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Genomic context

See Hspb8 in Genome Data Viewer
Location:
5 F; 5 56.41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (116546550..116560923, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (116408491..116422864, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B230112J18 gene Neighboring gene RIKEN cDNA 4933424N20 gene Neighboring gene STARR-seq mESC enhancer starr_14150 Neighboring gene STARR-seq mESC enhancer starr_14152 Neighboring gene STARR-seq mESC enhancer starr_14153 Neighboring gene predicted gene, 36841 Neighboring gene predicted gene, 42009 Neighboring gene serine/arginine repetitive matrix 4, opposite strand Neighboring gene serine/arginine repetitive matrix 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aggrephagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein folding chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock protein beta-8
Names
alpha-crystallin C chain
crystallin, alpha C
heat shock 27kDa protein 8
heat shock protein 20-like protein
small stress protein-like protein HSP22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030704.3NP_109629.1  heat shock protein beta-8

    See identical proteins and their annotated locations for NP_109629.1

    Status: VALIDATED

    Source sequence(s)
    AI326838, AK005052
    Consensus CDS
    CCDS19600.1
    UniProtKB/Swiss-Prot
    Q9JK92
    Related
    ENSMUSP00000037007.5, ENSMUST00000036991.5
    Conserved Domains (1) summary
    cd06480
    Location:80170
    ACD_HspB8_like; Alpha-crystallin domain (ACD) found in mammalian 21.6 KDa small heat shock protein (sHsp) HspB8, also denoted as Hsp22 in humans, and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    116546550..116560923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)