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Ghdc GH3 domain containing [ Mus musculus (house mouse) ]

Gene ID: 80860, updated on 2-Nov-2024

Summary

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Official Symbol
Ghdcprovided by MGI
Official Full Name
GH3 domain containingprovided by MGI
Primary source
MGI:MGI:1931556
See related
Ensembl:ENSMUSG00000017747 AllianceGenome:MGI:1931556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Lgp1e
Summary
Predicted to enable acid-amino acid ligase activity. Located in endoplasmic reticulum. Orthologous to human GHDC (GH3 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 11.2), kidney adult (RPKM 10.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ghdc in Genome Data Viewer
Location:
11 D; 11 63.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100656852..100661772, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100766026..100770973, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E8452 Neighboring gene STARR-positive B cell enhancer ABC_E5278 Neighboring gene STARR-positive B cell enhancer ABC_E8453 Neighboring gene hypocretin Neighboring gene signal transducer and activator of transcription 5B Neighboring gene STARR-positive B cell enhancer ABC_E8454 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100681071-100681254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100707044-100707332 Neighboring gene signal transducer and activator of transcription 5A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Cui Y, et al. Genomics, 2001 Dec. PMID 11735219
  2. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Miyoshi K, et al. Genomics, 2001 Jan 15. PMID 11161808
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acid-amino acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GH3 domain-containing protein
Names
D11lgp1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418306.1 → NP_001405235.1  GH3 domain-containing protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591466

  2. NM_031871.2 → NP_114077.1  GH3 domain-containing protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_114077.1

    Status: VALIDATED

    Source sequence(s)
    AL591466
    Consensus CDS
    CCDS25437.1
    UniProtKB/Swiss-Prot
    A2A5D7, Q99J23, Q99J92
    UniProtKB/TrEMBL
    Q3UNZ1, Q3UXS5
    Related
    ENSMUSP00000017891.8, ENSMUST00000017891.14
    Conserved Domains (2) summary
    cl21606
    Location:207 → 532
    PLN02247; indole-3-acetic acid-amido synthetase
    pfam03321
    Location:55 → 500
    GH3; GH3 auxin-responsive promoter

RNA

  1. NR_184712.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591466

  2. NR_184713.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591466

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100656852..100661772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J23.2 GenPept UniProtKB/Swiss-Prot:Q99J23

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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