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Selenok selenoprotein K [ Mus musculus (house mouse) ]

Gene ID: 80795, updated on 8-Feb-2024

Summary

Official Symbol
Selenokprovided by MGI
Official Full Name
selenoprotein Kprovided by MGI
Primary source
MGI:MGI:1931466
See related
Ensembl:ENSMUSG00000042682 AllianceGenome:MGI:1931466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Selk; Hsp30; HSPC030; 1110001C03Rik
Summary
The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Multiple pseudogenes of this locus have been identified. [provided by RefSeq, Sep 2017]
Expression
Broad expression in liver E18 (RPKM 94.4), CNS E18 (RPKM 45.8) and 23 other tissues See more
Orthologs
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Genomic context

See Selenok in Genome Data Viewer
Location:
14 A3; 14 18.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (29690337..29697031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (29968380..29975074)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35281 Neighboring gene STARR-seq mESC enhancer starr_36292 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:30781255-30781364 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:30781377-30781530 Neighboring gene ARP8 actin-related protein 8 Neighboring gene microRNA 6947 Neighboring gene interleukin 17 receptor B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotactic protein-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of store-operated calcium entry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within respiratory burst after phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
selenoprotein K
Names
heat shock protein, 30 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019979.2NP_064363.2  selenoprotein K

    See identical proteins and their annotated locations for NP_064363.2

    Status: REVIEWED

    Source sequence(s)
    AK003206, AK003280, BY095166
    Consensus CDS
    CCDS36844.1
    UniProtKB/Swiss-Prot
    Q8CI00, Q9JLJ1
    Related
    ENSMUSP00000107887.3, ENSMUST00000112268.4
    Conserved Domains (1) summary
    pfam10961
    Location:291
    DUF2763; Protein of unknown function (DUF2763)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    29690337..29697031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)