Format

Send to:

Choose Destination

TMEM121 transmembrane protein 121 [ Homo sapiens (human) ]

Gene ID: 80757, updated on 23-Nov-2021

Summary

Official Symbol
TMEM121provided by HGNC
Official Full Name
transmembrane protein 121provided by HGNC
Primary source
HGNC:HGNC:20511
See related
Ensembl:ENSG00000184986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hole; TMEM121A
Expression
Broad expression in brain (RPKM 1.4), spleen (RPKM 0.9) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMEM121 in Genome Data Viewer
Location:
14q32.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (105526583..105530202)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105992920..105996535)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cysteine rich protein 1 Neighboring gene tubulin epsilon and delta complex 1 Neighboring gene uncharacterized LOC105370697 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC4659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 121
Names
transmembrane protein 121A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331238.2NP_001318167.1  transmembrane protein 121

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL928654, BC004221
    Consensus CDS
    CCDS10006.1
    UniProtKB/Swiss-Prot
    Q9BTD3
    Conserved Domains (1) summary
    pfam14997
    Location:73267
    CECR6_TMEM121; CECR6/TMEM121 family
  2. NM_025268.4NP_079544.1  transmembrane protein 121

    See identical proteins and their annotated locations for NP_079544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL928654, BC004221, HY134492
    Consensus CDS
    CCDS10006.1
    UniProtKB/Swiss-Prot
    Q9BTD3
    Related
    ENSP00000376304.2, ENST00000392519.7
    Conserved Domains (1) summary
    pfam14997
    Location:73267
    CECR6_TMEM121; CECR6/TMEM121 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    105526583..105530202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720261.3XP_006720324.1  transmembrane protein 121 isoform X1

    See identical proteins and their annotated locations for XP_006720324.1

    UniProtKB/Swiss-Prot
    Q9BTD3
    Conserved Domains (1) summary
    pfam14997
    Location:73267
    CECR6_TMEM121; CECR6/TMEM121 family
Support Center