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IQCN IQ motif containing N [ Homo sapiens (human) ]

Gene ID: 80726, updated on 28-Jan-2023

Summary

Official Symbol
IQCNprovided by HGNC
Official Full Name
IQ motif containing Nprovided by HGNC
Primary source
HGNC:HGNC:29350
See related
Ensembl:ENSG00000130518 MIM:620160; AllianceGenome:HGNC:29350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPGF78; KIAA1683
Summary
Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 15.0), lung (RPKM 1.4) and 4 other tissues See more
Orthologs
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Genomic context

See IQCN in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18257098..18274452, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18391196..18408552, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18367908..18385262, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4C Neighboring gene uncharacterized LOC729966 Neighboring gene Sharpr-MPRA regulatory region 4774 Neighboring gene JunD proto-oncogene, AP-1 transcription factor subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
IQ domain-containing protein N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145304.2NP_001138776.1  IQ domain-containing protein N isoform a

    See identical proteins and their annotated locations for NP_001138776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC008397, AL136867, BC112932, DC403083
    Consensus CDS
    CCDS46017.1
    UniProtKB/Swiss-Prot
    Q9H0B3
    Related
    ENSP00000376213.2, ENST00000392413.5
    Conserved Domains (5) summary
    smart00015
    Location:11371156
    IQ; Calmodulin-binding motif
    PHA03247
    Location:351862
    PHA03247; large tegument protein UL36; Provisional
    COG5022
    Location:11181195
    COG5022; Myosin heavy chain [General function prediction only]
    pfam05109
    Location:276558
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00612
    Location:11161134
    IQ; IQ calmodulin-binding motif
  2. NM_001145305.2NP_001138777.1  IQ domain-containing protein N isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR, translation initiation at a downstream start codon and lack of an internal in-frame segment, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AK302431, AL136867, BC127100, DC403083
    Consensus CDS
    CCDS46018.1
    UniProtKB/Swiss-Prot
    Q9H0B3
    UniProtKB/TrEMBL
    A0JP07
    Related
    ENSP00000472912.1, ENST00000600359.7
    Conserved Domains (6) summary
    smart00015
    Location:904923
    IQ; Calmodulin-binding motif
    PHA03247
    Location:305816
    PHA03247; large tegument protein UL36; Provisional
    COG5022
    Location:885962
    COG5022; Myosin heavy chain [General function prediction only]
    pfam05109
    Location:230512
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd22307
    Location:34138
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
    pfam00612
    Location:883901
    IQ; IQ calmodulin-binding motif
  3. NM_025249.4NP_079525.1  IQ domain-containing protein N isoform b

    See identical proteins and their annotated locations for NP_079525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the internal coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AL136867, DB078391, DC403083
    Consensus CDS
    CCDS32958.1
    UniProtKB/Swiss-Prot
    Q9C0I0, Q9H0B3
    Related
    ENSP00000470780.1, ENST00000600328.7
    Conserved Domains (2) summary
    smart00015
    Location:950969
    IQ; Calmodulin-binding motif
    pfam00612
    Location:929947
    IQ; IQ calmodulin-binding motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    18257098..18274452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260084.2XP_005260141.1  IQ domain-containing protein N isoform X1

    See identical proteins and their annotated locations for XP_005260141.1

    UniProtKB/Swiss-Prot
    Q9H0B3
    Conserved Domains (5) summary
    smart00015
    Location:11371156
    IQ; Calmodulin-binding motif
    PHA03247
    Location:351862
    PHA03247; large tegument protein UL36; Provisional
    COG5022
    Location:11181195
    COG5022; Myosin heavy chain [General function prediction only]
    pfam05109
    Location:276558
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00612
    Location:11161134
    IQ; IQ calmodulin-binding motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    18391196..18408552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)