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IQCN IQ motif containing N [ Homo sapiens (human) ]

Gene ID: 80726, updated on 23-Nov-2021

Summary

Official Symbol
IQCNprovided by HGNC
Official Full Name
IQ motif containing Nprovided by HGNC
Primary source
HGNC:HGNC:29350
See related
Ensembl:ENSG00000130518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1683
Expression
Biased expression in testis (RPKM 15.0), lung (RPKM 1.4) and 4 other tissues See more
Orthologs
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Genomic context

See IQCN in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18257098..18274452, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18367908..18385262, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4C Neighboring gene uncharacterized LOC729966 Neighboring gene Sharpr-MPRA regulatory region 4774 Neighboring gene JunD proto-oncogene, AP-1 transcription factor subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
IQ domain-containing protein N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145304.2NP_001138776.1  IQ domain-containing protein N isoform a

    See identical proteins and their annotated locations for NP_001138776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC008397, AL136867, BC112932, DC403083
    Consensus CDS
    CCDS46017.1
    UniProtKB/Swiss-Prot
    Q9H0B3
    Related
    ENSP00000376213.2, ENST00000392413.5
    Conserved Domains (2) summary
    smart00015
    Location:11371156
    IQ; Calmodulin-binding motif
    pfam00612
    Location:11161134
    IQ; IQ calmodulin-binding motif
  2. NM_001145305.2NP_001138777.1  IQ domain-containing protein N isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR, translation initiation at a downstream start codon and lack of an internal in-frame segment, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AK302431, AL136867, BC127100, DC403083
    Consensus CDS
    CCDS46018.1
    UniProtKB/Swiss-Prot
    Q9H0B3
    UniProtKB/TrEMBL
    A0JP07
    Related
    ENSP00000472912.1, ENST00000600359.7
    Conserved Domains (2) summary
    smart00015
    Location:904923
    IQ; Calmodulin-binding motif
    pfam00612
    Location:883901
    IQ; IQ calmodulin-binding motif
  3. NM_025249.4NP_079525.1  IQ domain-containing protein N isoform b

    See identical proteins and their annotated locations for NP_079525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the internal coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AL136867, DB078391, DC403083
    Consensus CDS
    CCDS32958.1
    UniProtKB/Swiss-Prot
    Q9H0B3
    Related
    ENSP00000470780.1, ENST00000600328.7
    Conserved Domains (2) summary
    smart00015
    Location:950969
    IQ; Calmodulin-binding motif
    pfam00612
    Location:929947
    IQ; IQ calmodulin-binding motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18257098..18274452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260084.1XP_005260141.1  IQ domain-containing protein N isoform X1

    See identical proteins and their annotated locations for XP_005260141.1

    UniProtKB/Swiss-Prot
    Q9H0B3
    Conserved Domains (2) summary
    smart00015
    Location:11371156
    IQ; Calmodulin-binding motif
    pfam00612
    Location:11161134
    IQ; IQ calmodulin-binding motif
  2. XM_011528324.1XP_011526626.1  IQ domain-containing protein N isoform X2

    Conserved Domains (1) summary
    smart00015
    Location:10911110
    IQ; Calmodulin-binding motif
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