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ACAD10 acyl-CoA dehydrogenase family member 10 [ Homo sapiens (human) ]

Gene ID: 80724, updated on 13-Mar-2020

Summary

Official Symbol
ACAD10provided by HGNC
Official Full Name
acyl-CoA dehydrogenase family member 10provided by HGNC
Primary source
HGNC:HGNC:21597
See related
Ensembl:ENSG00000111271 MIM:611181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in kidney (RPKM 11.6), duodenum (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See ACAD10 in Genome Data Viewer
Location:
12q24.12
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (111686053..111757099)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112123857..112194911)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ataxin 2 Neighboring gene ATXN2 antisense RNA Neighboring gene BRCA1 associated protein Neighboring gene PEST containing nuclear protein pseudogene 1 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene microRNA 6761 Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene MAPK activated protein kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of a coronary artery disease risk variant.
NHGRI GWA Catalog
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
NHGRI GWA Catalog
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ALDH2

Homology

Clone Names

  • MGC5601

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-CoA dehydrogenase activity TAS
Traceable Author Statement
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
acyl-CoA dehydrogenase family member 10
Names
ACAD-10
acyl-Coenzyme A dehydrogenase family, member 10
NP_001130010.1
NP_079523.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136538.2NP_001130010.1  acyl-CoA dehydrogenase family member 10 isoform a

    See identical proteins and their annotated locations for NP_001130010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL832043, BC126358, CA419108, DA146693
    Consensus CDS
    CCDS44973.1
    UniProtKB/Swiss-Prot
    Q6JQN1
    Related
    ENSP00000389813.2, ENST00000455480.6
    Conserved Domains (5) summary
    PLN02876
    Location:2881087
    PLN02876; acyl-CoA dehydrogenase
    cd05154
    Location:317567
    ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins
    TIGR02247
    Location:41278
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
    cl09933
    Location:6941087
    ACAD; Acyl-CoA dehydrogenase
    cl21460
    Location:46238
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_025247.6NP_079523.3  acyl-CoA dehydrogenase family member 10 isoform b

    See identical proteins and their annotated locations for NP_079523.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AL832043, AY323912, CA419108, DA146693
    Consensus CDS
    CCDS31903.1
    UniProtKB/Swiss-Prot
    Q6JQN1
    Related
    ENSP00000325137.4, ENST00000313698.8
    Conserved Domains (5) summary
    PLN02876
    Location:2571056
    PLN02876; acyl-CoA dehydrogenase
    cd05154
    Location:286536
    ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins
    TIGR02247
    Location:41247
    HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
    cl09933
    Location:6631056
    ACAD; Acyl-CoA dehydrogenase
    cl21460
    Location:46236
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    111686053..111757099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001136542.1: Suppressed sequence

    Description
    NM_001136542.1: This RefSeq was permanently suppressed because it is 3' partial and would be a nonsense-mediated mRNA decay (NMD) candidate if fully extended.
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