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Herpud2 HERPUD family member 2 [ Mus musculus (house mouse) ]

Gene ID: 80517, updated on 12-May-2024


Official Symbol
Herpud2provided by MGI
Official Full Name
HERPUD family member 2provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000008429 AllianceGenome:MGI:1915393
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acts upstream of or within spermatogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; nervous system; and reproductive system. Orthologous to human HERPUD2 (HERPUD family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in testis adult (RPKM 53.4), adrenal adult (RPKM 48.5) and 28 other tissues See more
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Genomic context

See Herpud2 in Genome Data Viewer
9 A4; 9 10.25 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (25012412..25063109, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (25108126..25151813, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130101E03 gene Neighboring gene transmembrane protein 126B pseudogene Neighboring gene STARR-seq mESC enhancer starr_23595 Neighboring gene STARR-seq mESC enhancer starr_23596 Neighboring gene predicted gene 29642 Neighboring gene STARR-seq mESC enhancer starr_23597 Neighboring gene RIKEN cDNA 9130004C02 gene Neighboring gene high mobility group box 2 pseudogene Neighboring gene septin 7

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1)  1 citation
  • Targeted (2) 

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020586.2NP_065611.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

    See identical proteins and their annotated locations for NP_065611.1

    Status: VALIDATED

    Source sequence(s)
    AC113082, CT025561
    Consensus CDS
    Q8K2W2, Q9CSZ4, Q9D2D0, Q9JJC9
    ENSMUSP00000008573.8, ENSMUST00000008573.9
    Conserved Domains (2) summary
    Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
    UBQ; Ubiquitin homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000075.7 Reference GRCm39 C57BL/6J

    25012412..25063109 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510706.4XP_006510769.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X1

    Conserved Domains (1) summary
    Ubl_HERP2; ubiquitin-like (Ubl) domain found in homocysteine-inducible endoplasmic reticulum stress protein HERP2 and similar proteins