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ADAM33 ADAM metallopeptidase domain 33 [ Homo sapiens (human) ]

Gene ID: 80332, updated on 18-Aug-2020

Summary

Official Symbol
ADAM33provided by HGNC
Official Full Name
ADAM metallopeptidase domain 33provided by HGNC
Primary source
HGNC:HGNC:15478
See related
Ensembl:ENSG00000149451 MIM:607114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf153; DJ964F7.1
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Expression
Broad expression in endometrium (RPKM 33.9), gall bladder (RPKM 16.7) and 17 other tissues See more
Orthologs

Genomic context

See ADAM33 in Genome Data Viewer
Location:
20p13
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3667973..3682108, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3648620..3662755, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene attractin Neighboring gene splicing factor 3a, subunit 3 pseudogene 1 Neighboring gene GDNF family receptor alpha 4 Neighboring gene Sharpr-MPRA regulatory region 3812 Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene heat shock protein family A (Hsp70) member 12B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35308, FLJ36751, MGC71889, MGC149823, DKFZp434K0521

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 33
Names
ADAM 33
a disintegrin and metalloprotease 33
a disintegrin and metalloproteinase domain 33
disintegrin and reprolysin metalloproteinase family protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282447.3NP_001269376.1  disintegrin and metalloproteinase domain-containing protein 33 isoform gamma precursor

    See identical proteins and their annotated locations for NP_001269376.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform gamma), compared to isoform alpha. The encoded isoform (gamma) may undergo proteolytic processing similar to isoform alpha.
    Source sequence(s)
    AF466287, AK126487, AL356755
    Consensus CDS
    CCDS63219.1
    UniProtKB/Swiss-Prot
    Q9BZ11
    UniProtKB/TrEMBL
    A2A2L3
    Related
    ENSP00000369190.4, ENST00000379861.8
    Conserved Domains (5) summary
    smart00050
    Location:426500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502644
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:210407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:210409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83164
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_025220.5NP_079496.1  disintegrin and metalloproteinase domain-containing protein 33 isoform alpha preproprotein

    See identical proteins and their annotated locations for NP_079496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (alpha).
    Source sequence(s)
    AL356755, AY358314
    Consensus CDS
    CCDS13058.1
    UniProtKB/Swiss-Prot
    Q9BZ11
    Related
    ENSP00000348912.2, ENST00000356518.6
    Conserved Domains (5) summary
    smart00050
    Location:426500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502644
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:210407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:210409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83164
    Pep_M12B_propep; Reprolysin family propeptide
  3. NM_153202.4NP_694882.1  disintegrin and metalloproteinase domain-containing protein 33 isoform beta precursor

    See identical proteins and their annotated locations for NP_694882.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. It encodes isoform beta, which lacks an internal segment, but has the same N- and C-termini as isoform alpha. The encoded isoform (beta) may undergo proteolytic processing similar to isoform alpha.
    Source sequence(s)
    AK126487, AL356755, DB225158
    UniProtKB/Swiss-Prot
    Q9BZ11
    Related
    ENSP00000322550.5, ENST00000350009.6
    Conserved Domains (5) summary
    smart00050
    Location:426500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502643
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:210407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:210409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83164
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3667973..3682108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723640.1XP_006723703.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X3

    Conserved Domains (5) summary
    smart00050
    Location:436510
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:512654
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:223417
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223419
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83177
    Pep_M12B_propep; Reprolysin family propeptide
  2. XM_005260843.1XP_005260900.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X1

    Conserved Domains (5) summary
    smart00050
    Location:439513
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:515657
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:223420
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223422
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83177
    Pep_M12B_propep; Reprolysin family propeptide
  3. XM_011529373.2XP_011527675.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X9

    Conserved Domains (3) summary
    smart00050
    Location:105179
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:181323
    ACR; ADAM Cysteine-Rich Domain
    cl00064
    Location:186
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  4. XM_011529367.1XP_011527669.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X4

    Conserved Domains (5) summary
    smart00050
    Location:425499
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:501643
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:209406
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:209408
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:88163
    Pep_M12B_propep; Reprolysin family propeptide
  5. XM_011529366.1XP_011527668.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

    Conserved Domains (5) summary
    smart00050
    Location:438512
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:514656
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:222419
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:222421
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:88176
    Pep_M12B_propep; Reprolysin family propeptide
  6. XM_011529370.1XP_011527672.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X5

    See identical proteins and their annotated locations for XP_011527672.1

    Conserved Domains (5) summary
    smart00050
    Location:439513
    DISIN; Homologues of snake disintegrins
    cd04269
    Location:223420
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223422
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83177
    Pep_M12B_propep; Reprolysin family propeptide
    cl15456
    Location:515548
    ADAM_CR; ADAM cysteine-rich
  7. XM_011529371.2XP_011527673.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X6

    Conserved Domains (2) summary
    cd04269
    Location:223343
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:83177
    Pep_M12B_propep; Reprolysin family propeptide
  8. XM_017028080.2XP_016883569.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X7

  9. XM_017028081.2XP_016883570.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

  10. XM_006723644.2XP_006723707.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X10

    Conserved Domains (4) summary
    smart00050
    Location:439479
    DISIN; Homologues of snake disintegrins
    cd04269
    Location:223420
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223422
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83177
    Pep_M12B_propep; Reprolysin family propeptide
  11. XM_017028083.1XP_016883572.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X12

  12. XM_017028082.1XP_016883571.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X11

RNA

  1. XR_001754405.1 RNA Sequence

  2. XR_002958534.1 RNA Sequence

  3. XR_937152.1 RNA Sequence

  4. XR_937151.1 RNA Sequence

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