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WNT10A Wnt family member 10A [ Homo sapiens (human) ]

Gene ID: 80326, updated on 3-May-2020

Summary

Official Symbol
WNT10Aprovided by HGNC
Official Full Name
Wnt family member 10Aprovided by HGNC
Primary source
HGNC:HGNC:13829
See related
Ensembl:ENSG00000135925 MIM:606268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OODD; SSPS; STHAG4
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
Expression
Broad expression in skin (RPKM 3.0), placenta (RPKM 1.8) and 16 other tissues See more
Orthologs

Genomic context

See WNT10A in Genome Data Viewer
Location:
2q35
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218874116..218893931)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219745255..219758651)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3 Neighboring gene microRNA 9500 Neighboring gene ribosomal protein L23a pseudogene 31 Neighboring gene Wnt family member 6 Neighboring gene uncharacterized LOC107984111 Neighboring gene uncharacterized LOC105373882 Neighboring gene long intergenic non-protein coding RNA 1494 Neighboring gene RNA, U6 small nuclear 642, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Odonto-onycho-dermal dysplasia
MedGen: C0796093 OMIM: 257980 GeneReviews: Not available
Compare labs
Schopf-Schulz-Passarge syndrome
MedGen: C1857069 OMIM: 224750 GeneReviews: Not available
Compare labs
Tooth agenesis, selective, 4
MedGen: C1835492 OMIM: 150400 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Common variants in the trichohyalin gene are associated with straight hair in Europeans.
NHGRI GWA Catalog
Web-based, participant-driven studies yield novel genetic associations for common traits.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell differentiation IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
sebaceous gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tongue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Wnt-10a
Names
wingless-type MMTV integration site family, member 10A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012179.1 RefSeqGene

    Range
    5320..18396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_025216.3NP_079492.2  protein Wnt-10a precursor

    See identical proteins and their annotated locations for NP_079492.2

    Status: REVIEWED

    Source sequence(s)
    AC073128
    Consensus CDS
    CCDS2426.1
    UniProtKB/Swiss-Prot
    Q9GZT5
    Related
    ENSP00000258411.3, ENST00000258411.8
    Conserved Domains (1) summary
    pfam00110
    Location:63417
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218874116..218893931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511929.2XP_011510231.1  protein Wnt-10a isoform X1

    Conserved Domains (1) summary
    pfam00110
    Location:35385
    wnt; wnt family
  2. XM_011511930.1XP_011510232.1  protein Wnt-10a isoform X2

    Conserved Domains (1) summary
    cl19568
    Location:67127
    wnt; wnt family
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