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KLHL15 kelch like family member 15 [ Homo sapiens (human) ]

Gene ID: 80311, updated on 1-Aug-2020

Summary

Official Symbol
KLHL15provided by HGNC
Official Full Name
kelch like family member 15provided by HGNC
Primary source
HGNC:HGNC:29347
See related
Ensembl:ENSG00000174010 MIM:300980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-305
Summary
This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. [provided by RefSeq, Apr 2009]
Expression
Broad expression in bone marrow (RPKM 22.1), testis (RPKM 14.8) and 22 other tissues See more
Orthologs

Genomic context

See KLHL15 in Genome Data Viewer
Location:
Xp22.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (23983720..24027186, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24001833..24045303, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9 pseudogene 7 Neighboring gene apolipoprotein O Neighboring gene chromosome X open reading frame 58 Neighboring gene Sharpr-MPRA regulatory region 13558 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene ZFX antisense RNA 1 Neighboring gene zinc finger protein X-linked

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1677, MGC126148, MGC126149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kelch-like protein 15
Names
epididymis secretory protein Li 305
epididymis secretory sperm binding protein
kelch-like 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012625.1 RefSeqGene

    Range
    5001..48471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030624.3NP_085127.2  kelch-like protein 15

    See identical proteins and their annotated locations for NP_085127.2

    Status: REVIEWED

    Source sequence(s)
    AK057298, AL834313, BC109059
    Consensus CDS
    CCDS35217.1
    UniProtKB/Swiss-Prot
    Q96M94
    UniProtKB/TrEMBL
    V9HWF1
    Related
    ENSP00000332791.8, ENST00000328046.8
    Conserved Domains (2) summary
    sd00038
    Location:417474
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:33576
    BTB; Broad-Complex, Tramtrack and Bric a brac

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    23983720..24027186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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