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CCDC6 coiled-coil domain containing 6 [ Homo sapiens (human) ]

Gene ID: 8030, updated on 4-Oct-2020

Summary

Official Symbol
CCDC6provided by HGNC
Official Full Name
coiled-coil domain containing 6provided by HGNC
Primary source
HGNC:HGNC:18782
See related
Ensembl:ENSG00000108091 MIM:601985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4; PTC; TPC; TST1; D10S170
Summary
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in esophagus (RPKM 21.3), brain (RPKM 15.5) and 25 other tissues See more
Orthologs

Genomic context

See CCDC6 in Genome Data Viewer
Location:
10q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (59788747..59906556, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (61548505..61666414, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 9 Neighboring gene myoregulin Neighboring gene long intergenic non-protein coding RNA 1553 Neighboring gene Sharpr-MPRA regulatory region 4517 Neighboring gene ankyrin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32286

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 6
Names
papillary thyroid carcinoma-encoded protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027819.1 RefSeqGene

    Range
    5101..122910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005436.5NP_005427.2  coiled-coil domain-containing protein 6

    See identical proteins and their annotated locations for NP_005427.2

    Status: REVIEWED

    Source sequence(s)
    AC060231, AK292593, BC022284, BM672399
    Consensus CDS
    CCDS7257.1
    UniProtKB/Swiss-Prot
    Q16204
    UniProtKB/TrEMBL
    Q05CP8
    Related
    ENSP00000263102.6, ENST00000263102.7
    Conserved Domains (1) summary
    pfam09755
    Location:52337
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    59788747..59906556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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