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MTERF2 mitochondrial transcription termination factor 2 [ Homo sapiens (human) ]

Gene ID: 80298, updated on 5-Aug-2022

Summary

Official Symbol
MTERF2provided by HGNC
Official Full Name
mitochondrial transcription termination factor 2provided by HGNC
Primary source
HGNC:HGNC:30779
See related
Ensembl:ENSG00000120832 MIM:616929; AllianceGenome:HGNC:30779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mTERFL; MTERFD3
Summary
Enables DNA binding activity. Predicted to be involved in termination of mitochondrial transcription. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 8.7), skin (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See MTERF2 in Genome Data Viewer
Location:
12q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (106977277..106987146, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (106940911..106950780, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (107371055..107380924, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9924 Neighboring gene transmembrane protein 263 Neighboring gene cryptochrome circadian regulator 1 Neighboring gene uncharacterized LOC124903009

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14062

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in termination of mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription termination factor 2, mitochondrial
Names
MTERF domain containing 3
mTERF domain-containing protein 3, mitochondrial
mTERF-like
mitochondrial transcription termination factor-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033050.3NP_001028222.1  transcription termination factor 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001028222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007541, AK024124, BC025984
    Consensus CDS
    CCDS9111.1
    UniProtKB/Swiss-Prot
    Q49AM1, Q9H7Y9
    UniProtKB/TrEMBL
    A0A024RBL7
    Related
    ENSP00000240050.4, ENST00000240050.9
    Conserved Domains (1) summary
    cl19765
    Location:58360
    mTERF; mTERF
  2. NM_025198.5NP_079474.2  transcription termination factor 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079474.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' splice site, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007541, BC025984, DA074327
    Consensus CDS
    CCDS9111.1
    UniProtKB/Swiss-Prot
    Q49AM1, Q9H7Y9
    UniProtKB/TrEMBL
    A0A024RBL7
    Related
    ENSP00000376575.2, ENST00000392830.6
    Conserved Domains (1) summary
    cl19765
    Location:58360
    mTERF; mTERF

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    106977277..106987146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019987.2XP_016875476.1  transcription termination factor 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q49AM1, Q9H7Y9
    UniProtKB/TrEMBL
    A0A024RBL7
    Conserved Domains (1) summary
    cl19765
    Location:58360
    mTERF; mTERF
  2. XM_017019986.2XP_016875475.1  transcription termination factor 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q49AM1, Q9H7Y9
    UniProtKB/TrEMBL
    A0A024RBL7
    Conserved Domains (1) summary
    cl19765
    Location:58360
    mTERF; mTERF
  3. XM_017019985.3XP_016875474.1  transcription termination factor 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q49AM1, Q9H7Y9
    UniProtKB/TrEMBL
    A0A024RBL7
    Conserved Domains (1) summary
    cl19765
    Location:58360
    mTERF; mTERF
  4. XM_011538767.3XP_011537069.1  transcription termination factor 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011537069.1

    UniProtKB/Swiss-Prot
    Q49AM1, Q9H7Y9
    UniProtKB/TrEMBL
    A0A024RBL7
    Related
    ENSP00000447651.1, ENST00000552029.1
    Conserved Domains (1) summary
    cl19765
    Location:58360
    mTERF; mTERF

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    106940911..106950780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)