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TRIM45 tripartite motif containing 45 [ Homo sapiens (human) ]

Gene ID: 80263, updated on 13-Jun-2021

Summary

Official Symbol
TRIM45provided by HGNC
Official Full Name
tripartite motif containing 45provided by HGNC
Primary source
HGNC:HGNC:19018
See related
Ensembl:ENSG00000134253 MIM:609318
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF99
Summary
This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in endometrium (RPKM 2.4), thyroid (RPKM 2.2) and 24 other tissues See more
Orthologs
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Genomic context

See TRIM45 in Genome Data Viewer
Location:
1p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (117107711..117121789, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117653682..117664371, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD101 molecule Neighboring gene CD101 antisense RNA 1 Neighboring gene transcription termination factor 2 Neighboring gene microRNA 942 Neighboring gene ribosomal protein S15a pseudogene 9 Neighboring gene V-set domain containing T cell activation inhibitor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13181

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bone development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 45
Names
ring finger protein 99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028008.1 RefSeqGene

    Range
    5041..15730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145635.2NP_001139107.1  tripartite motif-containing protein 45 isoform 2

    See identical proteins and their annotated locations for NP_001139107.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK222901, AY669488, BC034943, BU165629, EC541819
    Consensus CDS
    CCDS44200.1
    UniProtKB/Swiss-Prot
    Q9H8W5
    Related
    ENSP00000358476.3, ENST00000369464.7
    Conserved Domains (4) summary
    smart00557
    Location:391479
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00021
    Location:189226
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00630
    Location:391476
    Filamin; Filamin/ABP280 repeat
    cl23765
    Location:240357
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  2. NM_025188.4NP_079464.2  tripartite motif-containing protein 45 isoform 1

    See identical proteins and their annotated locations for NP_079464.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK222901, AY669488, BU165629, EC541819
    Consensus CDS
    CCDS893.1
    UniProtKB/Swiss-Prot
    Q9H8W5
    Related
    ENSP00000256649.4, ENST00000256649.9
    Conserved Domains (4) summary
    smart00557
    Location:399497
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00021
    Location:189226
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00630
    Location:397494
    Filamin; Filamin/ABP280 repeat
    cl23765
    Location:240357
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    117107711..117121789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542199.2XP_011540501.1  tripartite motif-containing protein 45 isoform X1

    Conserved Domains (4) summary
    smart00557
    Location:295393
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00021
    Location:85122
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam00630
    Location:293390
    Filamin; Filamin/ABP280 repeat
    cl23765
    Location:136253
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RNA

  1. XR_246297.1 RNA Sequence

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