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CEP63 centrosomal protein 63 [ Homo sapiens (human) ]

Gene ID: 80254, updated on 16-Oct-2021

Summary

Official Symbol
CEP63provided by HGNC
Official Full Name
centrosomal protein 63provided by HGNC
Primary source
HGNC:HGNC:25815
See related
Ensembl:ENSG00000182923 Ensembl:ENSG00000288700 MIM:614724
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCKL6
Summary
This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 6.9), fat (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See CEP63 in Genome Data Viewer
Location:
3q22.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (134485724..134783169)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134204566..134293855)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene microRNA 4788 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene anaphase promoting complex subunit 13 Neighboring gene kyphoscoliosis peptidase Neighboring gene Sharpr-MPRA regulatory region 6102 Neighboring gene RNA, U6 small nuclear 1174, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 141 Neighboring gene EPH receptor B1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 20 loci that influence adult height.
GeneReviews: Not available
Seckel syndrome 6
MedGen: C3553582 OMIM: 614728 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13386, MGC78416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
centrosomal protein of 63 kDa
Names
centrosomal protein 63kDa
centrosome protein CEP63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032870.1 RefSeqGene

    Range
    4992..94281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042383.2NP_001035842.1  centrosomal protein of 63 kDa isoform c

    See identical proteins and their annotated locations for NP_001035842.1

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC109912, BC014050, BX499930, CX751767, N36992
    Consensus CDS
    CCDS43154.1
    UniProtKB/Swiss-Prot
    Q96MT8
    Related
    ENSP00000328382.5, ENST00000332047.10
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247495
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001042384.2NP_001035843.1  centrosomal protein of 63 kDa isoform d

    See identical proteins and their annotated locations for NP_001035843.1

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC139764, AK023738, BG182631, BX499930, CX751767
    Consensus CDS
    CCDS43152.1
    UniProtKB/Swiss-Prot
    Q96MT8
    Related
    ENSP00000346432.3, ENST00000354446.7
    Conserved Domains (2) summary
    COG1196
    Location:163453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
  3. NM_001042400.3NP_001035859.1  centrosomal protein of 63 kDa isoform b

    See identical proteins and their annotated locations for NP_001035859.1

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43153.1
    UniProtKB/Swiss-Prot
    Q96MT8
    Related
    ENSP00000372716.3, ENST00000383229.8
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163479
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001353108.3NP_001340037.1  centrosomal protein of 63 kDa isoform a

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS3086.1
    Related
    ENSP00000502085.1, ENST00000675561.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163528
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001353109.1NP_001340038.1  centrosomal protein of 63 kDa isoform e

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Related
    ENSP00000507263.1, ENST00000682458.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136463
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001353110.1NP_001340039.1  centrosomal protein of 63 kDa isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Consensus CDS
    CCDS43153.1
    Related
    ENSP00000508291.1, ENST00000684217.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163479
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001353111.2NP_001340040.1  centrosomal protein of 63 kDa isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43153.1
    Related
    ENSP00000507217.1, ENST00000684677.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163479
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001353112.2NP_001340041.1  centrosomal protein of 63 kDa isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43153.1
    Related
    ENSP00000507704.1, ENST00000683608.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163479
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001353113.1NP_001340042.1  centrosomal protein of 63 kDa isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Related
    ENSP00000507552.1, ENST00000683997.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136464
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001353117.2NP_001340046.1  centrosomal protein of 63 kDa isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Related
    ENSP00000427526.2, ENST00000514678.2
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136464
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001353118.1NP_001340047.1  centrosomal protein of 63 kDa isoform g

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Conserved Domains (2) summary
    pfam17045
    Location:27289
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:256504
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_001353119.2NP_001340048.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43154.1
    Related
    ENSP00000506728.1, ENST00000683861.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247495
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001353120.2NP_001340049.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43154.1
    Related
    ENSP00000507228.1, ENST00000682042.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247495
    SMC_N; RecF/RecN/SMC N terminal domain
  14. NM_001353121.2NP_001340050.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43154.1
    Related
    ENSP00000506828.1, ENST00000683177.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247495
    SMC_N; RecF/RecN/SMC N terminal domain
  15. NM_001353122.1NP_001340051.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Consensus CDS
    CCDS43154.1
    Related
    ENSP00000507703.1, ENST00000682858.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247495
    SMC_N; RecF/RecN/SMC N terminal domain
  16. NM_001353123.2NP_001340052.1  centrosomal protein of 63 kDa isoform d

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Consensus CDS
    CCDS43152.1
    Related
    ENSP00000482219.1, ENST00000620544.5
    Conserved Domains (2) summary
    COG1196
    Location:163453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
  17. NM_001353124.2NP_001340053.1  centrosomal protein of 63 kDa isoform d

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Consensus CDS
    CCDS43152.1
    Related
    ENSP00000423225.2, ENST00000512894.6
    Conserved Domains (2) summary
    COG1196
    Location:163453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
  18. NM_001353125.2NP_001340054.1  centrosomal protein of 63 kDa isoform h

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Related
    ENSP00000507256.1, ENST00000684492.1
    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:219467
    SMC_N; RecF/RecN/SMC N terminal domain
  19. NM_001353126.2NP_001340055.1  centrosomal protein of 63 kDa isoform i

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Conserved Domains (2) summary
    pfam17045
    Location:6159
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:42320
    SMC_N; RecF/RecN/SMC N terminal domain
  20. NM_025180.5NP_079456.2  centrosomal protein of 63 kDa isoform a

    See identical proteins and their annotated locations for NP_079456.2

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS3086.1
    UniProtKB/Swiss-Prot
    Q96MT8
    Related
    ENSP00000426129.1, ENST00000513612.7
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163528
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_148352.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
  2. NR_148353.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
  3. NR_148354.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Related
    ENST00000682013.1
  4. NR_148355.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Related
    ENST00000650279.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    134485724..134783169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247795.5XP_005247852.1  centrosomal protein of 63 kDa isoform X2

    Conserved Domains (2) summary
    pfam13094
    Location:253376
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    pfam17045
    Location:27289
    CEP63; Centrosomal protein of 63 kDa
  2. XM_017007252.1XP_016862741.1  centrosomal protein of 63 kDa isoform X9

    Conserved Domains (2) summary
    pfam13094
    Location:123246
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    pfam17045
    Location:1159
    CEP63; Centrosomal protein of 63 kDa
  3. XM_006713760.4XP_006713823.1  centrosomal protein of 63 kDa isoform X3

    See identical proteins and their annotated locations for XP_006713823.1

    UniProtKB/Swiss-Prot
    Q96MT8
    Related
    ENSP00000506896.1, ENST00000683596.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163528
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_005247799.3XP_005247856.1  centrosomal protein of 63 kDa isoform X9

    Conserved Domains (2) summary
    pfam13094
    Location:123246
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    pfam17045
    Location:1159
    CEP63; Centrosomal protein of 63 kDa
  5. XM_017007247.2XP_016862736.1  centrosomal protein of 63 kDa isoform X6

    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136463
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_024453779.1XP_024309547.1  centrosomal protein of 63 kDa isoform X14

    Related
    ENSP00000422685.2, ENST00000508778.2
    Conserved Domains (1) summary
    TIGR02169
    Location:27309
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  7. XM_024453769.1XP_024309537.1  centrosomal protein of 63 kDa isoform X4

    Related
    ENSP00000508034.1, ENST00000683190.1
    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135500
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_024453778.1XP_024309546.1  centrosomal protein of 63 kDa isoform X13

    Related
    ENSP00000507596.1, ENST00000682822.1
    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:219467
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_005247797.3XP_005247854.1  centrosomal protein of 63 kDa isoform X3

    See identical proteins and their annotated locations for XP_005247854.1

    UniProtKB/Swiss-Prot
    Q96MT8
    Related
    ENSP00000475903.1, ENST00000606977.5
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163528
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_017007248.2XP_016862737.1  centrosomal protein of 63 kDa isoform X6

    Related
    ENSP00000507548.1, ENST00000682402.1
    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136463
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_017007249.1XP_016862738.1  centrosomal protein of 63 kDa isoform X6

    Conserved Domains (2) summary
    pfam17045
    Location:18280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136463
    SMC_N; RecF/RecN/SMC N terminal domain
  12. XM_024453771.1XP_024309539.1  centrosomal protein of 63 kDa isoform X4

    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135500
    SMC_N; RecF/RecN/SMC N terminal domain
  13. XM_024453773.1XP_024309541.1  centrosomal protein of 63 kDa isoform X4

    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135500
    SMC_N; RecF/RecN/SMC N terminal domain
  14. XM_024453768.1XP_024309536.1  centrosomal protein of 63 kDa isoform X1

    Conserved Domains (2) summary
    pfam17045
    Location:29291
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:174539
    SMC_N; RecF/RecN/SMC N terminal domain
  15. XM_024453776.1XP_024309544.1  centrosomal protein of 63 kDa isoform X11

    Conserved Domains (2) summary
    pfam17045
    Location:29291
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:176490
    SMC_N; RecF/RecN/SMC N terminal domain
  16. XM_024453777.1XP_024309545.1  centrosomal protein of 63 kDa isoform X12

    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:108436
    SMC_N; RecF/RecN/SMC N terminal domain
  17. XM_024453772.1XP_024309540.1  centrosomal protein of 63 kDa isoform X7

    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135500
    SMC_N; RecF/RecN/SMC N terminal domain
  18. XM_024453775.1XP_024309543.1  centrosomal protein of 63 kDa isoform X10

    Related
    ENSP00000508161.1, ENST00000684170.1
    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135451
    SMC_N; RecF/RecN/SMC N terminal domain
  19. XM_024453770.1XP_024309538.1  centrosomal protein of 63 kDa isoform X5

    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:108435
    SMC_N; RecF/RecN/SMC N terminal domain
  20. XM_024453774.1XP_024309542.1  centrosomal protein of 63 kDa isoform X8

    Conserved Domains (2) summary
    pfam17045
    Location:1252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:108435
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_002959589.1 RNA Sequence

  2. XR_001740278.1 RNA Sequence

    Related
    ENST00000682319.1
  3. XR_002959586.1 RNA Sequence

  4. XR_002959587.1 RNA Sequence

  5. XR_002959588.1 RNA Sequence

    Related
    ENST00000682954.1
  6. XR_002959590.1 RNA Sequence

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