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PIGZ phosphatidylinositol glycan anchor biosynthesis class Z [ Homo sapiens (human) ]

Gene ID: 80235, updated on 17-Jun-2024

Summary

Official Symbol
PIGZprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Zprovided by HGNC
Primary source
HGNC:HGNC:30596
See related
Ensembl:ENSG00000119227 MIM:611671; AllianceGenome:HGNC:30596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMP3; PIG-Z; GPI-MT-IV
Summary
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 5.3), brain (RPKM 1.9) and 20 other tissues See more
Orthologs
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Genomic context

See PIGZ in Genome Data Viewer
Location:
3q29
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196946356..196968833, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199672412..199695067, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196673227..196695704, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196668731-196669404 Neighboring gene NCBP2 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196669405-196670078 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:196670753-196671426 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196674955-196675702 Neighboring gene Sharpr-MPRA regulatory region 11589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196695281-196695816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196695817-196696352 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196696353-196696888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21106 Neighboring gene 40S ribosomal protein SA-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
GPI mannosyltransferase 4
Names
GPI mannosyltransferase IV
SMP3 mannosyltransferase
dol-P-Man dependent GPI mannosyltransferase
phosphatidylinositol glycan, class Z
phosphatidylinositol-glycan biosynthesis class Z protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025163.4NP_079439.2  GPI mannosyltransferase 4

    See identical proteins and their annotated locations for NP_079439.2

    Status: REVIEWED

    Source sequence(s)
    AK022830, AK296867, BC018804, BG760692, BX493581
    Consensus CDS
    CCDS3324.1
    UniProtKB/Swiss-Prot
    Q86VD9, Q9H9G6
    Related
    ENSP00000413405.1, ENST00000412723.6
    Conserved Domains (1) summary
    cl21590
    Location:44391
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    196946356..196968833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513192.3XP_011511494.1  GPI mannosyltransferase 4 isoform X2

    See identical proteins and their annotated locations for XP_011511494.1

    Conserved Domains (1) summary
    cl21590
    Location:83430
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  2. XM_047448993.1XP_047304949.1  GPI mannosyltransferase 4 isoform X2

  3. XM_024453767.2XP_024309535.1  GPI mannosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21590
    Location:109456
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  4. XM_024453766.2XP_024309534.1  GPI mannosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21590
    Location:109456
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  5. XM_017007241.2XP_016862730.1  GPI mannosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21590
    Location:109456
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  6. XM_017007243.2XP_016862732.1  GPI mannosyltransferase 4 isoform X3

    UniProtKB/TrEMBL
    B4DL68
    Conserved Domains (1) summary
    cl21590
    Location:5241
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    199672412..199695067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347966.1XP_054203941.1  GPI mannosyltransferase 4 isoform X1

  2. XM_054347970.1XP_054203945.1  GPI mannosyltransferase 4 isoform X2

  3. XM_054347969.1XP_054203944.1  GPI mannosyltransferase 4 isoform X2

  4. XM_054347968.1XP_054203943.1  GPI mannosyltransferase 4 isoform X1

  5. XM_054347967.1XP_054203942.1  GPI mannosyltransferase 4 isoform X1

  6. XM_054347965.1XP_054203940.1  GPI mannosyltransferase 4 isoform X1

  7. XM_054347971.1XP_054203946.1  GPI mannosyltransferase 4 isoform X3

    UniProtKB/TrEMBL
    B4DL68