Format

Send to:

Choose Destination

PIGZ phosphatidylinositol glycan anchor biosynthesis class Z [ Homo sapiens (human) ]

Gene ID: 80235, updated on 23-Nov-2021

Summary

Official Symbol
PIGZprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Zprovided by HGNC
Primary source
HGNC:HGNC:30596
See related
Ensembl:ENSG00000119227 MIM:611671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMP3; PIG-Z; GPI-MT-IV
Summary
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 5.3), brain (RPKM 1.9) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PIGZ in Genome Data Viewer
Location:
3q29
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (196946356..196969411, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196673227..196695704, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene NCBP2 antisense RNA 1 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene Sharpr-MPRA regulatory region 11589 Neighboring gene Sharpr-MPRA regulatory region 2091 Neighboring gene ribosomal protein SA pseudogene 69 Neighboring gene ribosomal protein SA pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12768, MGC52163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-1,2-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mannosyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mannosyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in GPI anchor biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mannosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in preassembly of GPI anchor in ER membrane TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GPI mannosyltransferase 4
Names
GPI mannosyltransferase IV
SMP3 mannosyltransferase
dol-P-Man dependent GPI mannosyltransferase
phosphatidylinositol glycan, class Z
phosphatidylinositol-glycan biosynthesis class Z protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025163.4NP_079439.2  GPI mannosyltransferase 4

    See identical proteins and their annotated locations for NP_079439.2

    Status: REVIEWED

    Source sequence(s)
    AK022830, AK296867, BC018804, BG760692, BX493581
    Consensus CDS
    CCDS3324.1
    UniProtKB/Swiss-Prot
    Q86VD9
    UniProtKB/TrEMBL
    B4DL68
    Related
    ENSP00000413405.1, ENST00000412723.6
    Conserved Domains (1) summary
    cl21590
    Location:44391
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    196946356..196969411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007242.1XP_016862731.1  GPI mannosyltransferase 4 isoform X3

    Conserved Domains (1) summary
    cl21590
    Location:5241
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  2. XM_011513192.2XP_011511494.1  GPI mannosyltransferase 4 isoform X2

    See identical proteins and their annotated locations for XP_011511494.1

    Conserved Domains (1) summary
    cl21590
    Location:83430
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  3. XM_024453767.1XP_024309535.1  GPI mannosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21590
    Location:109456
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  4. XM_024453766.1XP_024309534.1  GPI mannosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21590
    Location:109456
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  5. XM_017007241.1XP_016862730.1  GPI mannosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21590
    Location:109456
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  6. XM_011513190.2XP_011511492.1  GPI mannosyltransferase 4 isoform X2

    See identical proteins and their annotated locations for XP_011511492.1

    Conserved Domains (1) summary
    cl21590
    Location:83430
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  7. XM_017007240.2XP_016862729.1  GPI mannosyltransferase 4 isoform X1

    Conserved Domains (1) summary
    cl21590
    Location:109456
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  8. XM_017007243.2XP_016862732.1  GPI mannosyltransferase 4 isoform X3

    Conserved Domains (1) summary
    cl21590
    Location:5241
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Support Center