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ACSF2 acyl-CoA synthetase family member 2 [ Homo sapiens (human) ]

Gene ID: 80221, updated on 7-Jun-2020

Summary

Official Symbol
ACSF2provided by HGNC
Official Full Name
acyl-CoA synthetase family member 2provided by HGNC
Primary source
HGNC:HGNC:26101
See related
Ensembl:ENSG00000167107 MIM:610465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACSMW; AVYV493
Expression
Broad expression in kidney (RPKM 73.1), thyroid (RPKM 24.6) and 18 other tissues See more
Orthologs

Genomic context

See ACSF2 in Genome Data Viewer
Location:
17q21.33
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50426158..50474845)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48503519..48552200)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene leucine rich repeat containing 59 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 9 Neighboring gene chondroadherin Neighboring gene Sharpr-MPRA regulatory region 9450 Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene MYCBP associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20920

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA ligase activity TAS
Traceable Author Statement
more info
 
butyrate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
medium-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
medium-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
medium-chain acyl-CoA ligase ACSF2, mitochondrial
Names
PPARG binding, long chain fatty acid acyl Co-A ligase like
acyl-CoA synthetase family member 2, mitochondrial
NP_001275897.1
NP_001275898.1
NP_001275899.1
NP_001275900.1
NP_001275901.1
NP_079425.3
XP_006722173.1
XP_011523596.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288968.1NP_001275897.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001275897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK294205, AK300625, AK308584
    Consensus CDS
    CCDS74103.1
    UniProtKB/Swiss-Prot
    Q96CM8
    Related
    ENSP00000401831.2, ENST00000427954.6
    Conserved Domains (2) summary
    cd05917
    Location:279631
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
    PRK08315
    Location:82640
    PRK08315; AMP-binding domain protein; Validated
  2. NM_001288969.1NP_001275898.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001275898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, and uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK294205, AK295258, AK300625, AK308584
    Consensus CDS
    CCDS74104.1
    UniProtKB/Swiss-Prot
    Q96CM8
    Related
    ENSP00000421884.1, ENST00000502667.5
    Conserved Domains (2) summary
    cd05917
    Location:241593
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
    PRK08315
    Location:57602
    PRK08315; AMP-binding domain protein; Validated
  3. NM_001288970.1NP_001275899.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons in the 5' and central coding regions, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
    Source sequence(s)
    AK294205, AK300145, AK300625, AK308584
    Consensus CDS
    CCDS74105.1
    UniProtKB/Swiss-Prot
    Q96CM8
    UniProtKB/TrEMBL
    B4DTB9, E9PF16
    Related
    ENSP00000425964.1, ENST00000504392.5
    Conserved Domains (2) summary
    cd05917
    Location:211563
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
    PRK08315
    Location:57572
    PRK08315; AMP-binding domain protein; Validated
  4. NM_001288971.1NP_001275900.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 5

    See identical proteins and their annotated locations for NP_001275900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    AK294205, AK300625, AK308584
    UniProtKB/Swiss-Prot
    Q96CM8
    Conserved Domains (1) summary
    cd05917
    Location:94446
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
  5. NM_001288972.1NP_001275901.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 5

    See identical proteins and their annotated locations for NP_001275901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    AK300625, AK308584, AY358660, DC296100
    UniProtKB/Swiss-Prot
    Q96CM8
    Conserved Domains (1) summary
    cd05917
    Location:94446
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
  6. NM_025149.6NP_079425.3  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_079425.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK300625, AK308584, AY358660
    Consensus CDS
    CCDS11567.1
    UniProtKB/Swiss-Prot
    Q96CM8
    Related
    ENSP00000300441.4, ENST00000300441.8
    Conserved Domains (1) summary
    cl27678
    Location:57615
    AMP-binding; AMP-binding enzyme

RNA

  1. NR_110232.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks several exons and contains an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK308584, AK311109
    Related
    ENST00000506085.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50426158..50474845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525294.2XP_011523596.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd05917
    Location:254600
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
    PRK08315
    Location:57609
    PRK08315; AMP-binding domain protein; Validated
  2. XM_006722110.4XP_006722173.1  medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl17068
    Location:254441
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. XR_429924.3 RNA Sequence

  2. XR_934565.2 RNA Sequence

  3. XR_934563.3 RNA Sequence

  4. XR_934566.3 RNA Sequence

  5. XR_934564.2 RNA Sequence

  6. XR_934567.2 RNA Sequence

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