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SIKE1 suppressor of IKBKE 1 [ Homo sapiens (human) ]

Gene ID: 80143, updated on 24-Nov-2020

Summary

Official Symbol
SIKE1provided by HGNC
Official Full Name
suppressor of IKBKE 1provided by HGNC
Primary source
HGNC:HGNC:26119
See related
Ensembl:ENSG00000052723 MIM:611656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIKE
Summary
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.5), lymph node (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See SIKE1 in Genome Data Viewer
Location:
1p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (114769479..114780685, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115312100..115323308, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NRAS proto-oncogene, GTPase Neighboring gene cold shock domain containing E1 Neighboring gene RNY1 pseudogene 13 Neighboring gene nuclear receptor subfamily 1 group H member 5, pseudogene Neighboring gene synaptonemal complex protein 1 Neighboring gene uncharacterized LOC105378915

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CSDE1

Homology

Clone Names

  • FLJ21168, DKFZp686A0768

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
suppressor of IKBKE 1
Names
suppressor of IKK epsilon

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102396.2NP_001095866.1  suppressor of IKBKE 1 isoform 1

    See identical proteins and their annotated locations for NP_001095866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI039175, AL096773, BC005934, CR749219, DA950119
    Consensus CDS
    CCDS41371.1
    UniProtKB/Swiss-Prot
    Q9BRV8
    Related
    ENSP00000358541.5, ENST00000369528.9
    Conserved Domains (1) summary
    pfam05769
    Location:2191
    DUF837; Protein of unknown function (DUF837)
  2. NM_025073.3NP_079349.2  suppressor of IKBKE 1 isoform 2

    See identical proteins and their annotated locations for NP_079349.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI039175, AL096773, BC005934, DA950119
    Consensus CDS
    CCDS878.1
    UniProtKB/Swiss-Prot
    Q9BRV8
    Related
    ENSP00000060969.5, ENST00000060969.5
    Conserved Domains (1) summary
    pfam05769
    Location:2187
    SIKE; SIKE family

RNA

  1. NR_049741.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, which results in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL096773, CR936771, DB459255
  2. NR_049742.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' coding region, compared to variant 1, which result in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI221103, AL096773, CR936771

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    114769479..114780685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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