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SIKE1 suppressor of IKBKE 1 [ Homo sapiens (human) ]

Gene ID: 80143, updated on 3-Nov-2024

Summary

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Official Symbol
SIKE1provided by HGNC
Official Full Name
suppressor of IKBKE 1provided by HGNC
Primary source
HGNC:HGNC:26119
See related
Ensembl:ENSG00000052723 MIM:611656; AllianceGenome:HGNC:26119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIKE
Summary
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.5), lymph node (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

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See SIKE1 in Genome Data Viewer
Location:
1p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (114769479..114780685, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (114780904..114792111, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115312100..115323306, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1549 Neighboring gene NRAS proto-oncogene, GTPase Neighboring gene MPRA-validated peak382 silencer Neighboring gene MPRA-validated peak383 silencer Neighboring gene cold shock domain containing E1 Neighboring gene RNY1 pseudogene 13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:115300157-115301150 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:115322492-115323058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:115323059-115323624 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:115332573-115333482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:115333483-115334390 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:115337845-115338062 Neighboring gene MPRA-validated peak384 silencer Neighboring gene nuclear receptor subfamily 1 group H member 5, pseudogene Neighboring gene synaptonemal complex protein 1 Neighboring gene uncharacterized LOC105378915

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer. Gayed DT, et al. Biosci Rep, 2019 Jan 31. PMID 30487159, Free PMC Article
  2. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. Huang J, et al. EMBO J, 2005 Dec 7. PMID 16281057, Free PMC Article
  3. Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Tang Y, et al. Cell Discov, 2019. PMID 30622739, Free PMC Article
  4. Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1). Marion JD, et al. J Biol Chem, 2013 Jun 21. PMID 23649622, Free PMC Article
  5. Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy. Deng KQ, et al. Nat Commun, 2016 Jun 1. PMID 27249321, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mRNA expression of individual inhibitory kappaB kinases and SIKE are associated with unique prognostic significance and may act as valuable prognostic biomarkers and potential targets for future therapeutic interventions in gastric cancer.
    Title: Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer.
  2. SIKE, a negative regulator of the interferon pathway, attenuates pathological cardiac hypertrophy.
    Title: Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy.
  3. Data indicate that suppressor of IKKepsilon (SIKE) inhibits TANK-binding kinase 1 (TBK1)-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essential to type I interferon production.
    Title: Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).
  4. Overexpression of SIKE inhibits virus- and Toll-like receptor 3-triggered interferon-stimulated response elements (ISRE) but not NF-kappa B activation.
    Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: CSDE1

Homology

Clone Names

  • FLJ21168, DKFZp686A0768

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
suppressor of IKBKE 1
Names
suppressor of IKK epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102396.2 → NP_001095866.1  suppressor of IKBKE 1 isoform 1

    See identical proteins and their annotated locations for NP_001095866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI039175, AL096773, BC005934, CR749219, DA950119
    Consensus CDS
    CCDS41371.1
    UniProtKB/Swiss-Prot
    Q9BRV8
    Related
    ENSP00000358541.5, ENST00000369528.9
    Conserved Domains (1) summary
    pfam05769
    Location:2 → 191
    DUF837; Protein of unknown function (DUF837)

  2. NM_025073.3 → NP_079349.2  suppressor of IKBKE 1 isoform 2

    See identical proteins and their annotated locations for NP_079349.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI039175, AL096773, BC005934, DA950119
    Consensus CDS
    CCDS878.1
    UniProtKB/Swiss-Prot
    Q5TEZ7, Q5TEZ9, Q68DZ4, Q9BRV8, Q9H778
    Related
    ENSP00000060969.6, ENST00000060969.6
    Conserved Domains (1) summary
    pfam05769
    Location:2 → 187
    SIKE; SIKE family

RNA

  1. NR_049741.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, which results in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL096773, CR936771, DB459255

  2. NR_049742.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' coding region, compared to variant 1, which result in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI221103, AL096773, CR936771

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    114769479..114780685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    114780904..114792111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BRV8.1 GenPept UniProtKB/Swiss-Prot:Q9BRV8

Gene LinkOut

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