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NR4A3 nuclear receptor subfamily 4 group A member 3 [ Homo sapiens (human) ]

Gene ID: 8013, updated on 2-Nov-2024

Summary

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Official Symbol
NR4A3provided by HGNC
Official Full Name
nuclear receptor subfamily 4 group A member 3provided by HGNC
Primary source
HGNC:HGNC:7982
See related
Ensembl:ENSG00000119508 MIM:600542; AllianceGenome:HGNC:7982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHN; CSMF; NOR1; MINOR
Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression
Biased expression in adrenal (RPKM 28.0), urinary bladder (RPKM 16.9) and 13 other tissues See more
Orthologs
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Genomic context

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See NR4A3 in Genome Data Viewer
Location:
9q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (99821885..99866891)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (111993520..112038527)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (102584167..102629173)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987012 Neighboring gene uncharacterized LOC101928438 Neighboring gene uncharacterized LOC124902234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:102431793-102432372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:102437510-102438010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28715 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:102581295-102581888 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:102581889-102582482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:102584885-102585397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:102595258-102596457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28716 Neighboring gene STX17 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr9:102678782-102679392 Neighboring gene syntaxin 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of oxidored-nitro domain containing protein 1 induces growth inhibition and apoptosis in human prostate cancer PC3 cells. Shan Z, et al. Oncol Rep, 2014 Nov. PMID 25118646
  2. Vascular effects of thrombin: involvement of NOR-1 in thrombin-induced mitogenic stimulus in vascular cells. Martorell L, et al. Front Biosci, 2008 Jan 1. PMID 17981763
  3. Nor1, a novel cytokine-responsive regulator of pancreatic β-cell mass and function mediated by disruption of mitochondrial networks. Duan T, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Jan 12. PMID 33241311
  4. Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects. Weyrich P, et al. BMC Med Genet, 2009 Aug 14. PMID 19682370, Free PMC Article
  5. Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma. Skaugen JM, et al. Cancer Cytopathol, 2021 Feb. PMID 32809265

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NOR1 promotes the osteoblastic differentiation of human periodontal ligament stem cells via TGF-beta signaling pathway.
    Title: NOR1 promotes the osteoblastic differentiation of human periodontal ligament stem cells via TGF-β signaling pathway.
  2. Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases.
    Title: Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases.
  3. Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation.
    Title: Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation.
  4. Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia.
    Title: Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia.
  5. RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis.
    Title: RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis.
  6. Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification.
    Title: Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification.
  7. Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.
    Title: Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.
  8. NRF1 Alleviated Oxidative Stress of Glioblastoma Cells by Regulating NOR1.
    Title: NRF1 Alleviated Oxidative Stress of Glioblastoma Cells by Regulating NOR1.
  9. Loss of NOR-1 represses muscle metabolism through mTORC1-mediated signaling and mitochondrial gene expression in C2C12 myotubes.
    Title: Loss of NOR-1 represses muscle metabolism through mTORC1-mediated signaling and mitochondrial gene expression in C2C12 myotubes.
  10. NR4A3 Expression Is Consistently Absent in Acinic Cell Carcinomas of the Breast: A Potential Nosologic Shift.
    Title: NR4A3 Expression Is Consistently Absent in Acinic Cell Carcinomas of the Breast: A Potential Nosologic Shift.
Submit: New GeneRIF Correction See all GeneRIFs (114)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Extraskeletal myxoid chondrosarcoma
MedGen: C1275278 OMIM: 612237 GeneReviews: Not available
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EBI GWAS Catalog

Description
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP response element binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nuclear glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables nuclear steroid receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to catecholamine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to corticotropin-releasing hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to corticotropin-releasing hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to leptin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in common myeloid progenitor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mast cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mast cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of monocyte aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 4 group A member 3
Names
chondrosarcoma, extraskeletal myxoid, fused to EWS
mitogen-induced nuclear orphan receptor
neuron-derived orphan receptor 1
nuclear hormone receptor NOR-1
translocated in extraskeletal chondrosarcoma

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028910.1 RefSeqGene

    Range
    5031..50037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006981.4 → NP_008912.2  nuclear receptor subfamily 4 group A member 3 isoform a

    See identical proteins and their annotated locations for NP_008912.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks the exon containing the translational start site compared to variant 3. The resulting isoform (a) is shorter at the N-terminus compared to isoform b.
    Source sequence(s)
    AK226108, AL358937, S81243, U12767
    Consensus CDS
    CCDS6743.1
    UniProtKB/Swiss-Prot
    A2A3I7, Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q92570, Q9UEK2, Q9UEK3
    Related
    ENSP00000378531.2, ENST00000395097.7
    Conserved Domains (2) summary
    cd06969
    Location:290 → 364
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:396 → 626
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. NM_173199.4 → NP_775291.1  nuclear receptor subfamily 4 group A member 3 isoform c

    See identical proteins and their annotated locations for NP_775291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as NOR-1alpha, lacks the exon containing the translational start site and differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (c) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform b.
    Source sequence(s)
    AL359710
    Consensus CDS
    CCDS6744.1
    UniProtKB/Swiss-Prot
    Q92570
    Related
    ENSP00000340301.4, ENST00000338488.8
    Conserved Domains (1) summary
    cd06969
    Location:290 → 364
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  3. NM_173200.3 → NP_775292.1  nuclear receptor subfamily 4 group A member 3 isoform b

    See identical proteins and their annotated locations for NP_775292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (b).
    Source sequence(s)
    AK226108, AL358937, S81243, U12767
    Consensus CDS
    CCDS6742.1
    UniProtKB/Swiss-Prot
    Q92570
    Related
    ENSP00000482027.1, ENST00000618101.4
    Conserved Domains (2) summary
    cd06969
    Location:301 → 375
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:407 → 637
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    99821885..99866891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015162.2 → XP_016870651.1  nuclear receptor subfamily 4 group A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A2A3I7, Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q92570, Q9UEK2, Q9UEK3
    Conserved Domains (2) summary
    cd06969
    Location:290 → 364
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:396 → 626
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    111993520..112038527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173198.1: Suppressed sequence

    Description
    NM_173198.1: This RefSeq was permanently suppressed because it represents an unsupported variant with non-consensus splice sites.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92570.3 GenPept UniProtKB/Swiss-Prot:Q92570

Gene LinkOut

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