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NRSN2 neurensin 2 [ Homo sapiens (human) ]

Gene ID: 80023, updated on 7-Jan-2024

Summary

Official Symbol
NRSN2provided by HGNC
Official Full Name
neurensin 2provided by HGNC
Primary source
HGNC:HGNC:16229
See related
Ensembl:ENSG00000125841 MIM:610666; AllianceGenome:HGNC:16229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf98; dJ1103G7.6
Summary
Predicted to be involved in nervous system development. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 20.9), adrenal (RPKM 7.5) and 22 other tissues See more
Orthologs
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Genomic context

See NRSN2 in Genome Data Viewer
Location:
20p13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (347111..354862)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (390459..398227)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (327755..335506)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12562 Neighboring gene NRSN2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12568 Neighboring gene Sharpr-MPRA regulatory region 7859/9812 Neighboring gene SRY-box transcription factor 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:326527-327290 Neighboring gene serine/arginine repetitive matrix protein 2-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:327291-328053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:328054-328816 Neighboring gene Sharpr-MPRA regulatory region 10349 Neighboring gene Sharpr-MPRA regulatory region 12668 Neighboring gene Sharpr-MPRA regulatory region 10396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:345627-346226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:362523-363521 Neighboring gene tribbles pseudokinase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:379646-380146 Neighboring gene CRISPRi-validated cis-regulatory element chr20.29 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:386661-386817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12575 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:388888-389530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:389531-390171 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:410614-411114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:411115-411615

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23329

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323679.2NP_001310608.1  neurensin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK026982, BC001963, BP251173
    UniProtKB/Swiss-Prot
    Q9GZP1
  2. NM_001323680.2NP_001310609.1  neurensin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK026982, BC001963, CD102518, DA479487
    Consensus CDS
    CCDS12996.1
    UniProtKB/Swiss-Prot
    A8K3B2, Q6FII5, Q9GZP1, Q9NUD3
    Conserved Domains (1) summary
    pfam14927
    Location:22155
    Neurensin
  3. NM_001323681.2NP_001310610.1  neurensin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK026982, BC001963, CD102518
    Consensus CDS
    CCDS12996.1
    UniProtKB/Swiss-Prot
    A8K3B2, Q6FII5, Q9GZP1, Q9NUD3
    Conserved Domains (1) summary
    pfam14927
    Location:22155
    Neurensin
  4. NM_001323682.2NP_001310611.1  neurensin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK026982, BC001963, BP202782
    Consensus CDS
    CCDS12996.1
    UniProtKB/Swiss-Prot
    A8K3B2, Q6FII5, Q9GZP1, Q9NUD3
    Related
    ENSP00000371722.2, ENST00000382285.7
    Conserved Domains (1) summary
    pfam14927
    Location:22155
    Neurensin
  5. NM_001323683.2NP_001310612.1  neurensin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL034548, AW292804
    Consensus CDS
    CCDS12996.1
    UniProtKB/Swiss-Prot
    A8K3B2, Q6FII5, Q9GZP1, Q9NUD3
    Conserved Domains (1) summary
    pfam14927
    Location:22155
    Neurensin
  6. NM_001323684.2NP_001310613.1  neurensin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL034548, AW292804, DA708181
    Consensus CDS
    CCDS12996.1
    UniProtKB/Swiss-Prot
    A8K3B2, Q6FII5, Q9GZP1, Q9NUD3
    Conserved Domains (1) summary
    pfam14927
    Location:22155
    Neurensin
  7. NM_001323685.2NP_001310614.1  neurensin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK026982, BC001963, DB172225
    Consensus CDS
    CCDS12996.1
    UniProtKB/Swiss-Prot
    A8K3B2, Q6FII5, Q9GZP1, Q9NUD3
    Conserved Domains (1) summary
    pfam14927
    Location:22155
    Neurensin
  8. NM_024958.3NP_079234.1  neurensin-2 isoform 1

    See identical proteins and their annotated locations for NP_079234.1

    Status: VALIDATED

    Source sequence(s)
    AL136915, BC001963, BE792891, DA708181
    Consensus CDS
    CCDS12996.1
    UniProtKB/Swiss-Prot
    A8K3B2, Q6FII5, Q9GZP1, Q9NUD3
    Related
    ENSP00000371728.3, ENST00000382291.7
    Conserved Domains (1) summary
    pfam14927
    Location:22155
    Neurensin

RNA

  1. NR_136649.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL034548, BC001963, DA708181

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    347111..354862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    390459..398227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)