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DGLUCY D-glutamate cyclase [ Homo sapiens (human) ]

Gene ID: 80017, updated on 13-Feb-2019

Summary

Official Symbol
DGLUCYprovided by HGNC
Official Full Name
D-glutamate cyclaseprovided by HGNC
Primary source
HGNC:HGNC:20498
See related
Ensembl:ENSG00000133943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf159
Expression
Ubiquitous expression in heart (RPKM 27.3), kidney (RPKM 11.9) and 24 other tissues See more
Orthologs

Genomic context

See DGLUCY in Genome Data Viewer
Location:
14q32.11
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (91060283..91225396)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91526677..91691976)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene ribosomal protein S18 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2321 Neighboring gene ribosomal protein S6 kinase A5 Neighboring gene RNA, U7 small nuclear 30 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 11B Neighboring gene G protein-coupled receptor 68 Neighboring gene coiled-coil domain containing 88C Neighboring gene uncharacterized LOC107984673

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20950, FLJ39943, FLJ39975, DKFZp686I02128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-glutamate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
glutamate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
D-glutamate cyclase, mitochondrial
Names
UPF0317 protein C14orf159, mitochondrial
NP_001095836.1
NP_001095837.1
NP_001095838.1
NP_001095839.1
NP_001273399.1
NP_001273400.1
NP_001273401.1
NP_001273402.1
NP_001345239.1
NP_001345240.1
NP_001345241.1
NP_079228.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102366.2NP_001095836.1  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001095836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (a). Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AL121784, AL602721, BC065558, BX642394, DA296867, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000428974.1, ENST00000523816.5
    Conserved Domains (2) summary
    pfam07286
    Location:118255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298608
    DUF4392; Domain of unknown function (DUF4392)
  2. NM_001102367.2NP_001095837.1  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001095837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AL121784, BC010614, BX642394, DB258432, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000427953.1, ENST00000522322.5
    Conserved Domains (2) summary
    pfam07286
    Location:118255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298608
    DUF4392; Domain of unknown function (DUF4392)
  3. NM_001102368.2NP_001095838.1  D-glutamate cyclase, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001095838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is longer than isoform a. Variants 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AB210031, BC065558, BX642394, DA296867, DR003467
    Consensus CDS
    CCDS41979.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    UniProtKB/TrEMBL
    Q4LE40
    Related
    ENSP00000256324.9, ENST00000256324.14
    Conserved Domains (2) summary
    pfam07286
    Location:118260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303613
    DUF4392; Domain of unknown function (DUF4392)
  4. NM_001102369.2NP_001095839.1  D-glutamate cyclase, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001095839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate in-frame splice site, and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK023200, AL121784, BC065558, BX642394, DA296867, DA641301, DR003467
    Consensus CDS
    CCDS45150.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000429453.1, ENST00000520328.5
    Conserved Domains (2) summary
    pfam07286
    Location:118242
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:286556
    DUF4392; Domain of unknown function (DUF4392)
  5. NM_001286470.1NP_001273399.1  D-glutamate cyclase, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001273399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is longer than isoform a. Variants 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AA192653, AK123532, AL121784, AL602721, BC065558, BX161393, DA296867, DR003467
    Consensus CDS
    CCDS41979.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    UniProtKB/TrEMBL
    B3KVU6
    Related
    ENSP00000428263.1, ENST00000518868.5
    Conserved Domains (2) summary
    pfam07286
    Location:118260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303613
    DUF4392; Domain of unknown function (DUF4392)
  6. NM_001286471.1NP_001273400.1  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001273400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AA192653, AL121784, AY358516, BC065558, BX161393, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000429655.1, ENST00000523771.5
    Conserved Domains (2) summary
    pfam07286
    Location:118255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298608
    DUF4392; Domain of unknown function (DUF4392)
  7. NM_001286472.1NP_001273401.1  D-glutamate cyclase, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, uses an alternate in-frame splice site, and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    BX247989, DA296867, DR003467
    Consensus CDS
    CCDS66693.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000430137.1, ENST00000521077.6
    Conserved Domains (2) summary
    pfam07286
    Location:118259
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303573
    DUF4392; Domain of unknown function (DUF4392)
  8. NM_001286473.1NP_001273402.1  D-glutamate cyclase, mitochondrial isoform e

    See identical proteins and their annotated locations for NP_001273402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, and lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI825879, BC009182, DA296867
    Consensus CDS
    CCDS73677.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000429098.1, ENST00000518665.6
    Conserved Domains (1) summary
    cl01790
    Location:1277
    DUF1445; Protein of unknown function (DUF1445)
  9. NM_001358310.1NP_001345239.1  D-glutamate cyclase, mitochondrial isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL135818
    Consensus CDS
    CCDS41979.1
    Conserved Domains (2) summary
    pfam07286
    Location:118260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303613
    DUF4392; Domain of unknown function (DUF4392)
  10. NM_001358311.1NP_001345240.1  D-glutamate cyclase, mitochondrial isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL135818
    Consensus CDS
    CCDS32141.1
    Conserved Domains (2) summary
    pfam07286
    Location:118255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298608
    DUF4392; Domain of unknown function (DUF4392)
  11. NM_001358312.1NP_001345241.1  D-glutamate cyclase, mitochondrial isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL135818
    Consensus CDS
    CCDS41979.1
    Conserved Domains (2) summary
    pfam07286
    Location:118260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303613
    DUF4392; Domain of unknown function (DUF4392)
  12. NM_024952.7NP_079228.4  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_079228.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AK022564, AL121784, AL602721, BX642394, DA296867, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000404343.2, ENST00000428926.6
    Conserved Domains (2) summary
    pfam07286
    Location:118255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298608
    DUF4392; Domain of unknown function (DUF4392)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    91060283..91225396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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