Format

Send to:

Choose Destination

WWC2 WW and C2 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 80014, updated on 5-Jan-2020

Summary

Official Symbol
WWC2provided by HGNC
Official Full Name
WW and C2 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:24148
See related
Ensembl:ENSG00000151718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOMB
Summary
This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]
Expression
Broad expression in lung (RPKM 16.2), kidney (RPKM 8.8) and 23 other tissues See more
Orthologs

Genomic context

See WWC2 in Genome Data Viewer
Location:
4q35.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (183098640..183320777)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184020463..184241930)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene CIBAR1 pseudogene 2 Neighboring gene uncharacterized LOC105377578 Neighboring gene Sharpr-MPRA regulatory region 3150 Neighboring gene WWC2 antisense RNA 2 Neighboring gene WWC2 antisense RNA 1 Neighboring gene DNA-directed RNA polymerase II subunit 1-like Neighboring gene claudin 22 Neighboring gene claudin 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22029, FLJ34082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein WWC2
Names
BH3-only member B protein
WW, C2 and coiled-coil domain containing 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051586.1 RefSeqGene

    Range
    5623..227143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024949.6NP_079225.5  protein WWC2

    See identical proteins and their annotated locations for NP_079225.5

    Status: REVIEWED

    Source sequence(s)
    AC019193, AC093844, AK074260, AK091401, AK126057, AL832424, BC053873, BC107683, BM046889, DN999977
    Consensus CDS
    CCDS34109.2
    UniProtKB/Swiss-Prot
    Q6AWC2
    Related
    ENSP00000384222.3, ENST00000403733.8
    Conserved Domains (6) summary
    cd08680
    Location:700823
    C2_Kibra; C2 domain found in Human protein Kibra
    pfam00397
    Location:1241
    WW; WW domain
    pfam11068
    Location:351428
    YlqD; YlqD protein
    cl00057
    Location:10341129
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl01720
    Location:10931168
    Phage_Nu1; Phage DNA packaging protein Nu1
    cl19219
    Location:283385
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    183098640..183320777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532269.3XP_011530571.1  protein WWC2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AWC2
    Related
    ENSP00000398577.2, ENST00000448232.6
    Conserved Domains (6) summary
    cd08680
    Location:700823
    C2_Kibra; C2 domain found in Human protein Kibra
    pfam00397
    Location:1241
    WW; WW domain
    pfam11068
    Location:351428
    YlqD; YlqD protein
    cl00057
    Location:10581153
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl01720
    Location:11171192
    Phage_Nu1; Phage DNA packaging protein Nu1
    cl19219
    Location:283385
    DUF342; Protein of unknown function (DUF342)
  2. XM_024454225.1XP_024309993.1  protein WWC2 isoform X2

    Conserved Domains (4) summary
    cd08680
    Location:602725
    C2_Kibra; C2 domain found in Human protein Kibra
    cl01720
    Location:10191094
    Phage_Nu1; Phage DNA packaging protein Nu1
    cl00057
    Location:9601055
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl25732
    Location:66317
    SMC_N; RecF/RecN/SMC N terminal domain
Support Center