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CCNP cyclin P [ Homo sapiens (human) ]

Gene ID: 79935, updated on 8-Dec-2022

Summary

Official Symbol
CCNPprovided by HGNC
Official Full Name
cyclin Pprovided by HGNC
Primary source
HGNC:HGNC:25805
See related
Ensembl:ENSG00000105219 AllianceGenome:HGNC:25805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNTD2
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CCNP in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40222208..40226689, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43042709..43047189, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40728115..40732596, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 10 Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene AKT serine/threonine kinase 2 Neighboring gene uncharacterized LOC107985289 Neighboring gene microRNA 641

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Homology

Clone Names

  • FLJ13265

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-P
Names
cyclin N-terminal domain containing 2
cyclin N-terminal domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411133.1NP_001398062.1  cyclin-P isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC118344
    Consensus CDS
    CCDS92618.1
    UniProtKB/TrEMBL
    M0QZM5
  2. NM_024877.4NP_079153.2  cyclin-P isoform 2

    See identical proteins and their annotated locations for NP_079153.2

    Status: VALIDATED

    Source sequence(s)
    AI924992, AK301833, BM709160, BU732215
    Consensus CDS
    CCDS12551.2
    UniProtKB/Swiss-Prot
    B4DX65, Q9H8S5
    Related
    ENSP00000396755.2, ENST00000430325.7
    Conserved Domains (1) summary
    pfam00134
    Location:103203
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40222208..40226689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723395.4XP_006723458.3  cyclin-P isoform X1

    Related
    ENSP00000470643.2, ENST00000599263.6
  2. XM_047439457.1XP_047295413.1  cyclin-P isoform X4

    UniProtKB/TrEMBL
    A0A024R0I4
    Related
    ENSP00000221818.1, ENST00000221818.5
  3. XM_047439456.1XP_047295412.1  cyclin-P isoform X3

  4. XM_047439455.1XP_047295411.1  cyclin-P isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43042709..43047189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)