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ACTR5 ARP5 actin related protein 5 homolog [ Homo sapiens (human) ]

Gene ID: 79913, updated on 7-Oct-2018

Summary

Official Symbol
ACTR5provided by HGNC
Official Full Name
ARP5 actin related protein 5 homologprovided by HGNC
Primary source
HGNC:HGNC:14671
See related
Ensembl:ENSG00000101442 Vega:OTTHUMG00000032456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Arp5; INO80M
Expression
Ubiquitous expression in testis (RPKM 7.1), lymph node (RPKM 4.1) and 25 other tissues See more
Orthologs

Genomic context

See ACTR5 in Genome Data Viewer
Location:
20q11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (38748454..38772446)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37376933..37401089)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 112/113 Neighboring gene solute carrier family 32 member 1 Neighboring gene RNA, 7SK small nuclear pseudogene 173 Neighboring gene protein phosphatase 1 regulatory subunit 16B Neighboring gene RNA, 7SL, cytoplasmic 116, pseudogene Neighboring gene family with sequence similarity 83 member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
    DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
    Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • UCH proteinases, organism-specific biosystem (from REACTOME)
    UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
UV-damage excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin-related protein 5
Names
INO80 complex subunit M
hARP5
sarcoma antigen NY-SAR-16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024855.3NP_079131.3  actin-related protein 5

    See identical proteins and their annotated locations for NP_079131.3

    Status: VALIDATED

    Source sequence(s)
    AK022847, BC038402, BF529768
    Consensus CDS
    CCDS13308.1
    UniProtKB/Swiss-Prot
    Q9H9F9
    Related
    ENSP00000243903.4, OTTHUMP00000030976, ENST00000243903.5, OTTHUMT00000079205
    Conserved Domains (1) summary
    COG5277
    Location:32569
    COG5277; Actin-related protein [Cytoskeleton]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    38748454..38772446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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