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ACTR5 actin related protein 5 [ Homo sapiens (human) ]

Gene ID: 79913, updated on 5-Mar-2024

Summary

Official Symbol
ACTR5provided by HGNC
Official Full Name
actin related protein 5provided by HGNC
Primary source
HGNC:HGNC:14671
See related
Ensembl:ENSG00000101442 MIM:619730; AllianceGenome:HGNC:14671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Arp5; INO80M
Summary
Involved in UV-damage excision repair and double-strand break repair. Located in cytoplasm and nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.1), lymph node (RPKM 4.1) and 25 other tissues See more
Orthologs
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Genomic context

See ACTR5 in Genome Data Viewer
Location:
20q11.23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38748460..38772520)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (40478618..40502676)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (37377103..37401163)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 40 Neighboring gene GINS complex subunit 2 (Psf2 homolog) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12900 Neighboring gene GATA motif-containing MPRA enhancer 112/113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12901 Neighboring gene MPRA-validated peak4211 silencer Neighboring gene VISTA enhancer hs2620 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:37342659-37343160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37354984-37355521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37355736-37356396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37357057-37357716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37360147-37360672 Neighboring gene solute carrier family 32 member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:37376699-37377200 Neighboring gene RN7SK pseudogene 173 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37408141-37408805 Neighboring gene uncharacterized LOC124904902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:37409138-37409638 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:37409639-37410139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37410633-37411244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37411245-37411854 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37432653-37433515 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37433516-37434377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37434958-37435796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17863 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37446609-37447156 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:37447157-37447704 Neighboring gene protein phosphatase 1 regulatory subunit 16B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17865 Neighboring gene Sharpr-MPRA regulatory region 4490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37499114-37499684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17873 Neighboring gene RNA, 7SL, cytoplasmic 116, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin-related protein 5
Names
ARP5 actin related protein 5 homolog
INO80 complex subunit M
hARP5
sarcoma antigen NY-SAR-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024855.4NP_079131.3  actin-related protein 5

    See identical proteins and their annotated locations for NP_079131.3

    Status: VALIDATED

    Source sequence(s)
    AK022847, AL133519, BC038402, BF529768
    Consensus CDS
    CCDS13308.1
    UniProtKB/Swiss-Prot
    Q86WF7, Q8IUY5, Q8N724, Q9BRN0, Q9BVB7, Q9H9F9
    Related
    ENSP00000243903.4, ENST00000243903.6
    Conserved Domains (1) summary
    COG5277
    Location:32569
    COG5277; Actin-related protein [Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    38748460..38772520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    40478618..40502676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)