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BTNL8 butyrophilin like 8 [ Homo sapiens (human) ]

Gene ID: 79908, updated on 8-Jul-2021

Summary

Official Symbol
BTNL8provided by HGNC
Official Full Name
butyrophilin like 8provided by HGNC
Primary source
HGNC:HGNC:26131
See related
Ensembl:ENSG00000113303 MIM:615606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTN9.2
Expression
Biased expression in duodenum (RPKM 27.0), small intestine (RPKM 20.3) and 3 other tissues See more
Orthologs
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Genomic context

See BTNL8 in Genome Data Viewer
Location:
5q35.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (180899097..180952166)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180326159..180377906)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 847 Neighboring gene hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA Neighboring gene ZFP62 zinc finger protein Neighboring gene ribosomal protein S29 pseudogene 12 Neighboring gene TERF2 interacting protein pseudogene Neighboring gene transmembrane protein 69 pseudogene Neighboring gene ARPP19 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21458, FLJ51528, MGC149619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
butyrophilin-like protein 8
Names
B7-H5 costimulatory molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040462.3NP_001035552.1  butyrophilin-like protein 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001035552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the middle portion of the coding region compared to variant 1, that results in a frameshift. It encodes isoform 2, previously known as the long form, which is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK025111, AY358523
    Consensus CDS
    CCDS43413.1
    UniProtKB/Swiss-Prot
    Q6UX41
    Related
    ENSP00000342197.4, ENST00000340184.9
    Conserved Domains (3) summary
    cd05713
    Location:33132
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:26131
    IG_like; Immunoglobulin like
    cd13733
    Location:289460
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  2. NM_001159707.2NP_001153179.1  butyrophilin-like protein 8 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the middle portion of the coding region compared to variant 1, that results in a frameshift. It encodes isoform 3, which is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK025111, AK298687, BC119696, DA425770
    Consensus CDS
    CCDS54957.1
    UniProtKB/Swiss-Prot
    Q6UX41
    Related
    ENSP00000425207.1, ENST00000511704.5
    Conserved Domains (1) summary
    cd13733
    Location:173344
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  3. NM_001159708.2NP_001153180.1  butyrophilin-like protein 8 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AK025111, BC119697, DA425770
    Consensus CDS
    CCDS54956.1
    UniProtKB/Swiss-Prot
    Q6UX41
    Related
    ENSP00000424585.1, ENST00000508408.5
    Conserved Domains (2) summary
    cd05713
    Location:33132
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:26131
    IG_like; Immunoglobulin like
  4. NM_001159709.2NP_001153181.1  butyrophilin-like protein 8 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate in-frame exon in the 5' coding region and uses an alternate start codon compared to variant 1. This variant (5) also uses an alternate splice site in the middle portion of the coding region compared to variant 1, that results in a frameshift. It encodes isoform 5, which is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK025111, AK296597
    Consensus CDS
    CCDS54958.1
    UniProtKB/Swiss-Prot
    Q6UX41
    Related
    ENSP00000383543.3, ENST00000400707.7
    Conserved Domains (1) summary
    cd13733
    Location:164335
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  5. NM_001159710.2NP_001153182.1  butyrophilin-like protein 8 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at downstream start codon, compared to variant 1. This variant (6) also uses an alternate splice site in the middle portion of the coding region compared to variant 1, that results in a frameshift. It encodes isoform 6, which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK025111, AK298687
    Consensus CDS
    CCDS54959.1
    UniProtKB/Swiss-Prot
    Q6UX41
    Related
    ENSP00000435098.2, ENST00000533815.2
    Conserved Domains (1) summary
    cd13733
    Location:105276
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  6. NM_024850.3NP_079126.1  butyrophilin-like protein 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_079126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1, previously known as the short form.
    Source sequence(s)
    AK025111, DA425770
    Consensus CDS
    CCDS4459.1
    UniProtKB/Swiss-Prot
    Q6UX41
    Related
    ENSP00000231229.4, ENST00000231229.8
    Conserved Domains (2) summary
    cd05713
    Location:33132
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:26131
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    180899097..180952166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534653.2XP_011532955.1  butyrophilin-like protein 8 isoform X5

    Conserved Domains (1) summary
    cd13733
    Location:81252
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  2. XM_011534649.2XP_011532951.1  butyrophilin-like protein 8 isoform X1

    Conserved Domains (3) summary
    cd05713
    Location:33132
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:26131
    IG_like; Immunoglobulin like
    cd13733
    Location:251422
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  3. XM_011534650.2XP_011532952.1  butyrophilin-like protein 8 isoform X2

    Conserved Domains (3) summary
    smart00410
    Location:1181
    IG_like; Immunoglobulin like
    cd13733
    Location:239410
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl11960
    Location:182
    Ig; Immunoglobulin domain
  4. XM_011534651.3XP_011532953.1  butyrophilin-like protein 8 isoform X3

    Conserved Domains (1) summary
    cd13733
    Location:178349
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
  5. XM_011534652.3XP_011532954.1  butyrophilin-like protein 8 isoform X4

    Conserved Domains (1) summary
    cd13733
    Location:170341
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
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