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LPCAT1 lysophosphatidylcholine acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 79888, updated on 27-Jun-2020

Summary

Official Symbol
LPCAT1provided by HGNC
Official Full Name
lysophosphatidylcholine acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:25718
See related
Ensembl:ENSG00000153395 MIM:610472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AYTL2; lpcat; AGPAT9; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT
Summary
This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]
Expression
Broad expression in lung (RPKM 73.0), spleen (RPKM 32.6) and 18 other tissues See more
Orthologs

Genomic context

See LPCAT1 in Genome Data Viewer
Location:
5p15.33
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (1461427..1523960, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1461542..1525644, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8068 Neighboring gene solute carrier family 6 member 3 Neighboring gene microRNA 6075 Neighboring gene CRISPRi-validated cis-regulatory element chr5.422 Neighboring gene uncharacterized LOC107986397

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12443, FLJ41609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-acylglycerophosphocholine O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
1-alkenylglycerophosphocholine O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
1-alkylglycerophosphocholine O-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
1-alkylglycerophosphocholine O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
plasmalogen synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
surfactant homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lysophosphatidylcholine acyltransferase 1
Names
1-acylglycerol-3-phosphate O-acyltransferase
1-acylglycerophosphocholine O-acyltransferase
1-alkenylglycerophosphocholine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
LPC acyltransferase 1
acetyl-CoA:lyso-PAF acetyltransferase
acetyl-CoA:lyso-platelet-activating factor acetyltransferase
acyltransferase-like 2
lyso-PAF acetyltransferase
lysoPC acyltransferase 1
phosphonoformate immuno-associated protein 3
NP_079106.3
XP_005248430.1
XP_011512434.1
XP_011512436.1
XP_016865368.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051622.1 RefSeqGene

    Range
    5018..67551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024830.5NP_079106.3  lysophosphatidylcholine acyltransferase 1

    See identical proteins and their annotated locations for NP_079106.3

    Status: REVIEWED

    Source sequence(s)
    AB244719, BC020166, BI770498, CA425992, CR982813
    Consensus CDS
    CCDS3864.1
    UniProtKB/Swiss-Prot
    Q8NF37
    Related
    ENSP00000283415.3, ENST00000283415.4
    Conserved Domains (4) summary
    cd07991
    Location:103314
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:58242
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam13499
    Location:421479
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:432483
    EF-hand_8; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    1461427..1523960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248373.3XP_005248430.1  lysophosphatidylcholine acyltransferase 1 isoform X3

    See identical proteins and their annotated locations for XP_005248430.1

    UniProtKB/TrEMBL
    D3DTC2
    Conserved Domains (4) summary
    cd07991
    Location:55266
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:10194
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam13499
    Location:373431
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:384435
    EF-hand_8; EF-hand domain pair
  2. XM_011514134.1XP_011512436.1  lysophosphatidylcholine acyltransferase 1 isoform X2

    Conserved Domains (4) summary
    cd07991
    Location:62273
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:17201
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam13499
    Location:380438
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:391442
    EF-hand_8; EF-hand domain pair
  3. XM_011514132.1XP_011512434.1  lysophosphatidylcholine acyltransferase 1 isoform X1

    Conserved Domains (4) summary
    cd07991
    Location:140351
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:95279
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam13499
    Location:458516
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:469520
    EF-hand_8; EF-hand domain pair
  4. XM_017009879.2XP_016865368.1  lysophosphatidylcholine acyltransferase 1 isoform X4

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187547.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    8167..48346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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