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BORA BORA aurora kinase A activator [ Homo sapiens (human) ]

Gene ID: 79866, updated on 1-Jun-2020

Summary

Official Symbol
BORAprovided by HGNC
Official Full Name
BORA aurora kinase A activatorprovided by HGNC
Primary source
HGNC:HGNC:24724
See related
Ensembl:ENSG00000136122 MIM:610510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C13orf34
Summary
BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in lymph node (RPKM 4.2), appendix (RPKM 3.1) and 24 other tissues See more
Orthologs

Genomic context

See BORA in Genome Data Viewer
Location:
13q21.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (72727749..72756198)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73301981..73330328)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 80, pseudogene Neighboring gene mitotic spindle organizing protein 1 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with meiotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286746.3NP_001273675.2  protein aurora borealis isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL138695, BC007119, BC056876, BX648605, CF529405
    Consensus CDS
    CCDS73583.1
    Related
    ENSP00000498664.1, ENST00000651477.1
    Conserved Domains (1) summary
    pfam15280
    Location:7213
    BORA_N; Protein aurora borealis N-terminus
  2. NM_001286747.1NP_001273676.1  protein aurora borealis isoform 3

    See identical proteins and their annotated locations for NP_001273676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK298608, AL138695, BC007119, BM923278, CF529405
    Consensus CDS
    CCDS66560.1
    UniProtKB/Swiss-Prot
    Q6PGQ7
    Related
    ENSP00000498882.1, ENST00000652266.1
    Conserved Domains (1) summary
    pfam15280
    Location:17143
    BORA_N; Protein aurora borealis N-terminus
  3. NM_001366664.2NP_001353593.1  protein aurora borealis isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL138695
  4. NM_024808.5NP_079084.4  protein aurora borealis isoform 1

    Status: VALIDATED

    Source sequence(s)
    BC007119, BC056876, BM923278, CF529405
    Consensus CDS
    CCDS9446.2
    Related
    ENSP00000375082.6, ENST00000390667.11
    Conserved Domains (1) summary
    pfam15280
    Location:7213
    BORA_N; Protein aurora borealis N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    72727749..72756198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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