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BORA BORA aurora kinase A activator [ Homo sapiens (human) ]

Gene ID: 79866, updated on 2-Nov-2024

Summary

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Official Symbol
BORAprovided by HGNC
Official Full Name
BORA aurora kinase A activatorprovided by HGNC
Primary source
HGNC:HGNC:24724
See related
Ensembl:ENSG00000136122 MIM:610510; AllianceGenome:HGNC:24724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C13orf34
Summary
BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in lymph node (RPKM 4.2), appendix (RPKM 3.1) and 24 other tissues See more
Orthologs
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Genomic context

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See BORA in Genome Data Viewer
Location:
13q21.33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (72727923..72756196)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (71949448..71977692)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73302061..73330334)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 80, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73301228-73301409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7814 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:73355230-73356144 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73426017-73426548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:73426549-73427078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7816 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73509249-73509443 Neighboring gene NANOG hESC enhancer GRCh37_chr13:73534622-73535123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73610339-73611015 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Bora downregulation results in radioresistance by promoting repair of double strand breaks. Cairns J, et al. PLoS One, 2015. PMID 25742493, Free PMC Article
  2. Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas. Zhang QX, et al. Oncotarget, 2017 Jul 4. PMID 28402276, Free PMC Article
  3. Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry. Tavernier N, et al. Nat Commun, 2021 Mar 26. PMID 33771996, Free PMC Article
  4. Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein. Qin B, et al. J Biol Chem, 2013 May 31. PMID 23592782, Free PMC Article
  5. Inhibition of Polo-like kinase 1 during the DNA damage response is mediated through loss of Aurora A recruitment by Bora. Bruinsma W, et al. Oncogene, 2017 Mar 30. PMID 27721411, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aurora A kinase activation: Different means to different ends.
    Title: Aurora A kinase activation: Different means to different ends.
  2. Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.
    Title: Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.
  3. our findings demonstrated that Bora was overexpressed and served as an independent biomarker for poor prognosis in multiple adenocarcinomas.
    Title: Cell cycle protein Bora serves as a novel poor prognostic factor in multiple adenocarcinomas.
  4. the mechanism of Plk1 activation and the potential role of Bora phosphorylation by Cdk1, is reported.
    Title: Mitotic entry: The interplay between Cdk1, Plk1 and Bora.
  5. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.
    Title: Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.
  6. Bora was found to play a significant role in radiosensitivity through the regulation of MDC1 and DNA repair.
    Title: Bora downregulation results in radioresistance by promoting repair of double strand breaks.
  7. Activation of Plk1 by Aurora-A may function as a bistable switch
    Title: Bora and Aurora-A continue to activate Plk1 in mitosis.
  8. Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex.
    Title: Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex.
  9. Following UV irradiation, ataxia telangiectasia-mutated- and Rad3-related protein phosphorylates Bora at Thr-501. The phosphorylated Thr-501 is subsequently recognized by the E3 ubiquitin ligase SCF-beta-TRCP, which targets Bora for degradation.
    Title: Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.
  10. Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22624

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in meiotic spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein aurora borealis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286746.3 → NP_001273675.2  protein aurora borealis isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL138695, BC007119, BC056876, BX648605, CF529405
    Consensus CDS
    CCDS9446.3
    UniProtKB/Swiss-Prot
    B4DQ30, Q5W0P3, Q5W0P4, Q6PGQ7, Q86YC6, Q96IW9, Q9H640
    UniProtKB/TrEMBL
    A8K631
    Related
    ENSP00000498664.1, ENST00000651477.1
    Conserved Domains (1) summary
    pfam15280
    Location:7 → 213
    BORA_N; Protein aurora borealis N-terminus

  2. NM_001286747.2 → NP_001273676.1  protein aurora borealis isoform 3

    See identical proteins and their annotated locations for NP_001273676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK298608, BC007119, CF529405
    Consensus CDS
    CCDS66560.1
    UniProtKB/TrEMBL
    A8K631
    Related
    ENSP00000498882.1, ENST00000652266.1
    Conserved Domains (1) summary
    pfam15280
    Location:17 → 143
    BORA_N; Protein aurora borealis N-terminus

  3. NM_001366664.2 → NP_001353593.1  protein aurora borealis isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL138695
    UniProtKB/TrEMBL
    A8K631

  4. NM_024808.5 → NP_079084.4  protein aurora borealis isoform 1

    Status: VALIDATED

    Source sequence(s)
    BC007119, BC056876, BM923278, CF529405
    Consensus CDS
    CCDS9446.3
    UniProtKB/Swiss-Prot
    B4DQ30, Q5W0P3, Q5W0P4, Q6PGQ7, Q86YC6, Q96IW9, Q9H640
    UniProtKB/TrEMBL
    A8K631
    Related
    ENSP00000375082.6, ENST00000390667.11
    Conserved Domains (1) summary
    pfam15280
    Location:7 → 213
    BORA_N; Protein aurora borealis N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    72727923..72756196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    71949448..71977692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGQ7.2 GenPept UniProtKB/Swiss-Prot:Q6PGQ7

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