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ZDHHC11 zinc finger DHHC-type containing 11 [ Homo sapiens (human) ]

Gene ID: 79844, updated on 22-Sep-2022

Summary

Official Symbol
ZDHHC11provided by HGNC
Official Full Name
zinc finger DHHC-type containing 11provided by HGNC
Primary source
HGNC:HGNC:19158
See related
Ensembl:ENSG00000188818 AllianceGenome:HGNC:19158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF399
Summary
Enables signaling adaptor activity. Involved in antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung (RPKM 2.8), duodenum (RPKM 2.5) and 24 other tissues See more
Orthologs
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Genomic context

See ZDHHC11 in Genome Data Viewer
Location:
5p15.33
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (795605..860563, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (701646..757038, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (795720..851101, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene uncharacterized LOC101929898 Neighboring gene zinc finger DHHC-type containing 11B Neighboring gene bromodomain containing 9 pseudogene 2 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene bromodomain containing 9 Neighboring gene Sharpr-MPRA regulatory region 1606 Neighboring gene thyroid hormone receptor interactor 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13153

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC11
Names
DHHC-11
probable palmitoyltransferase ZDHHC11
zinc finger DHHC domain-containing protein 11
zinc finger protein 399
zinc finger, DHHC domain containing 11
NP_001380421.1
NP_079062.1
XP_024301977.1
XP_024301978.1
XP_024301980.1
XP_024301981.1
XP_024301982.1
XP_024301983.1
XP_024301984.1
XP_024301985.1
XP_024301986.1
XP_047273702.1
XP_047273703.1
XP_047273704.1
XP_047273705.1
XP_047273706.1
XP_047273707.1
XP_047273708.1
XP_047273709.1
XP_047273710.1
XP_047273711.1
XP_047273712.1
XP_047273713.1
XP_047273714.1
XP_047273715.1
XP_047273716.1
XP_047273717.1
XP_047273718.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393492.1NP_001380421.1  palmitoyltransferase ZDHHC11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010427, AC026740, AC122719
    Conserved Domains (1) summary
    pfam01529
    Location:193330
    DHHC; DHHC palmitoyltransferase
  2. NM_024786.3NP_079062.1  palmitoyltransferase ZDHHC11 isoform 2

    See identical proteins and their annotated locations for NP_079062.1

    Status: VALIDATED

    Source sequence(s)
    AC010427, AC026740, AC122719
    Consensus CDS
    CCDS3857.1
    UniProtKB/Swiss-Prot
    Q6UWR9, Q9H8X9
    Related
    ENSP00000283441.8, ENST00000283441.13
    Conserved Domains (1) summary
    pfam01529
    Location:120275
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    795605..860563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417747.1XP_047273703.1  palmitoyltransferase ZDHHC11 isoform X1

  2. XM_047417746.1XP_047273702.1  palmitoyltransferase ZDHHC11 isoform X1

  3. XM_024446212.2XP_024301980.1  palmitoyltransferase ZDHHC11 isoform X5

    UniProtKB/Swiss-Prot
    Q6UWR9
    Conserved Domains (1) summary
    pfam01529
    Location:120275
    zf-DHHC; DHHC palmitoyltransferase
  4. XM_047417749.1XP_047273705.1  palmitoyltransferase ZDHHC11 isoform X4

  5. XM_024446210.2XP_024301978.1  palmitoyltransferase ZDHHC11 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:193330
    DHHC; DHHC palmitoyltransferase
  6. XM_024446209.2XP_024301977.1  palmitoyltransferase ZDHHC11 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:193316
    zf-DHHC; DHHC palmitoyltransferase
  7. XM_047417762.1XP_047273718.1  palmitoyltransferase ZDHHC11 isoform X21

  8. XM_047417761.1XP_047273717.1  palmitoyltransferase ZDHHC11 isoform X21

  9. XM_047417758.1XP_047273714.1  palmitoyltransferase ZDHHC11 isoform X20

  10. XM_047417760.1XP_047273716.1  palmitoyltransferase ZDHHC11 isoform X22

  11. XM_047417759.1XP_047273715.1  palmitoyltransferase ZDHHC11 isoform X21

    Related
    ENST00000503758.6
  12. XM_047417748.1XP_047273704.1  palmitoyltransferase ZDHHC11 isoform X2

  13. XM_047417754.1XP_047273710.1  palmitoyltransferase ZDHHC11 isoform X12

  14. XM_047417752.1XP_047273708.1  palmitoyltransferase ZDHHC11 isoform X9

  15. XM_047417755.1XP_047273711.1  palmitoyltransferase ZDHHC11 isoform X15

  16. XM_047417753.1XP_047273709.1  palmitoyltransferase ZDHHC11 isoform X11

  17. XM_047417751.1XP_047273707.1  palmitoyltransferase ZDHHC11 isoform X7

  18. XM_047417756.1XP_047273712.1  palmitoyltransferase ZDHHC11 isoform X17

  19. XM_024446214.2XP_024301982.1  palmitoyltransferase ZDHHC11 isoform X10

    Conserved Domains (1) summary
    pfam01529
    Location:193263
    zf-DHHC; DHHC palmitoyltransferase
  20. XM_047417750.1XP_047273706.1  palmitoyltransferase ZDHHC11 isoform X6

  21. XM_024446216.2XP_024301984.1  palmitoyltransferase ZDHHC11 isoform X14

    Conserved Domains (1) summary
    pfam01529
    Location:193261
    zf-DHHC; DHHC palmitoyltransferase
  22. XM_024446213.2XP_024301981.1  palmitoyltransferase ZDHHC11 isoform X8

    Conserved Domains (1) summary
    pfam01529
    Location:193261
    zf-DHHC; DHHC palmitoyltransferase
  23. XM_047417757.1XP_047273713.1  palmitoyltransferase ZDHHC11 isoform X19

  24. XM_024446215.2XP_024301983.1  palmitoyltransferase ZDHHC11 isoform X13

    Conserved Domains (1) summary
    pfam01529
    Location:193254
    zf-DHHC; DHHC palmitoyltransferase
  25. XM_024446217.2XP_024301985.1  palmitoyltransferase ZDHHC11 isoform X16

    Conserved Domains (1) summary
    cl19890
    Location:193245
    zf-DHHC; DHHC palmitoyltransferase
  26. XM_024446218.2XP_024301986.1  palmitoyltransferase ZDHHC11 isoform X18

    Conserved Domains (1) summary
    cl19890
    Location:193245
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. XR_007058638.1 RNA Sequence

  2. XR_007058637.1 RNA Sequence

  3. XR_007058640.1 RNA Sequence

  4. XR_007058639.1 RNA Sequence

  5. XR_007058636.1 RNA Sequence

  6. XR_007058641.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    701646..757038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)