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MOB3B MOB kinase activator 3B [ Homo sapiens (human) ]

Gene ID: 79817, updated on 5-Aug-2022

Summary

Official Symbol
MOB3Bprovided by HGNC
Official Full Name
MOB kinase activator 3Bprovided by HGNC
Primary source
HGNC:HGNC:23825
See related
Ensembl:ENSG00000120162 MIM:617652; AllianceGenome:HGNC:23825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOB1D; C9orf35; MOBKL2B
Summary
The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 14.2), duodenum (RPKM 9.8) and 20 other tissues See more
Orthologs
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Genomic context

See MOB3B in Genome Data Viewer
Location:
9p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (27325209..27529814, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (27335803..27540380, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27325207..27529812, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 32 Neighboring gene equatorin Neighboring gene dapper homolog 3-like Neighboring gene Sharpr-MPRA regulatory region 13504 Neighboring gene interferon kappa Neighboring gene chromosome 9 open reading frame 72 repeat instability region Neighboring gene C9orf72-SMCR8 complex subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
EBI GWAS Catalog
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13204, FLJ23916, MGC32960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MOB kinase activator 3B
Names
MOB kinase activator-like 2B
MOB1, Mps One Binder kinase activator-like 2B
mob1 homolog 2b
monopolar spindle 1 binding, MOB1, domain containing
mps one binder kinase activator-like 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024761.5NP_079037.3  MOB kinase activator 3B

    See identical proteins and their annotated locations for NP_079037.3

    Status: REVIEWED

    Source sequence(s)
    AK023266, AL163192, BF511468, CN260547, DB266074
    Consensus CDS
    CCDS6520.1
    UniProtKB/Swiss-Prot
    Q86TA1, Q9H8V4
    Related
    ENSP00000262244.5, ENST00000262244.6
    Conserved Domains (1) summary
    pfam03637
    Location:35207
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    27325209..27529814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423892.1XP_047279848.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q9H8V4
  2. XM_047423895.1XP_047279851.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q9H8V4
  3. XM_047423894.1XP_047279850.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q9H8V4
  4. XM_047423891.1XP_047279847.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q9H8V4
  5. XM_047423893.1XP_047279849.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q9H8V4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    27335803..27540380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)