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ACBD4 acyl-CoA binding domain containing 4 [ Homo sapiens (human) ]

Gene ID: 79777, updated on 13-Mar-2020

Summary

Official Symbol
ACBD4provided by HGNC
Official Full Name
acyl-CoA binding domain containing 4provided by HGNC
Primary source
HGNC:HGNC:23337
See related
Ensembl:ENSG00000181513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMFT0700
Summary
This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in liver (RPKM 7.3), duodenum (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See ACBD4 in Genome Data Viewer
Location:
17q21.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45132600..45144181)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43209967..43221548)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene N-myristoyltransferase 1 Neighboring gene phospholipase C delta 3 Neighboring gene microRNA 6784 Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene uncharacterized LOC112268203 Neighboring gene HEXIM P-TEFb complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13322, FLJ90623

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-CoA-binding domain-containing protein 4
Names
acyl-Coenzyme A binding domain containing 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135705.3NP_001129177.1  acyl-CoA-binding domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001129177.1

    Status: REVIEWED

    Source sequence(s)
    BC029164, BF514946, DC393065
    Consensus CDS
    CCDS42348.1
    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Q0
    Related
    ENSP00000314440.8, ENST00000321854.12
    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  2. NM_001135706.3NP_001129178.1  acyl-CoA-binding domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001129178.1

    Status: REVIEWED

    Source sequence(s)
    AK296167, BC041143
    Consensus CDS
    CCDS45710.1
    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Y4, B4DJP3
    Related
    ENSP00000465484.1, ENST00000586346.5
    Conserved Domains (2) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
    cl00464
    Location:103199
    URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...
  3. NM_001135707.3NP_001129179.1  acyl-CoA-binding domain-containing protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001129179.1

    Status: REVIEWED

    Source sequence(s)
    AC142472, AK075104, BC041143, CN293965, DC393065
    Consensus CDS
    CCDS45711.1
    UniProtKB/Swiss-Prot
    Q8NC06
    Related
    ENSP00000366154.3, ENST00000376955.8
    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  4. NM_001321352.2NP_001308281.1  acyl-CoA-binding domain-containing protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BC041143, DB128538
    Consensus CDS
    CCDS45710.1
    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Y4
    Related
    ENSP00000465610.1, ENST00000591859.5
    Conserved Domains (2) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
    cl00464
    Location:103199
    URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...
  5. NM_001321353.2NP_001308282.1  acyl-CoA-binding domain-containing protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC142472, BC041143, DB128538
    Consensus CDS
    CCDS45710.1
    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Y4
    Related
    ENSP00000405969.1, ENST00000431281.5
    Conserved Domains (2) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
    cl00464
    Location:103199
    URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...
  6. NM_001378111.1NP_001365040.1  acyl-CoA-binding domain-containing protein 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC142472
  7. NM_001378112.1NP_001365041.1  acyl-CoA-binding domain-containing protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC142472
  8. NM_024722.4NP_078998.1  acyl-CoA-binding domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_078998.1

    Status: REVIEWED

    Source sequence(s)
    AK023384, BC041143, DC421936
    Consensus CDS
    CCDS42348.1
    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Q0
    Related
    ENSP00000381367.2, ENST00000398322.7
    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45132600..45144181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025088.1XP_016880577.1  acyl-CoA-binding domain-containing protein 4 isoform X3

    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Y4
    Conserved Domains (2) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
    cl00464
    Location:103199
    URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...
  2. XM_017025089.2XP_016880578.1  acyl-CoA-binding domain-containing protein 4 isoform X4

  3. XM_017025091.1XP_016880580.1  acyl-CoA-binding domain-containing protein 4 isoform X8

    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Q0
    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  4. XM_017025084.1XP_016880573.1  acyl-CoA-binding domain-containing protein 4 isoform X1

  5. XM_017025095.1XP_016880584.1  acyl-CoA-binding domain-containing protein 4 isoform X11

  6. XM_017025087.1XP_016880576.1  acyl-CoA-binding domain-containing protein 4 isoform X2

    Conserved Domains (2) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
    cl00464
    Location:103199
    URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...
  7. XM_017025097.1XP_016880586.1  acyl-CoA-binding domain-containing protein 4 isoform X13

    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  8. XM_017025090.1XP_016880579.1  acyl-CoA-binding domain-containing protein 4 isoform X6

  9. XM_017025096.1XP_016880585.1  acyl-CoA-binding domain-containing protein 4 isoform X12

  10. XM_006722085.2XP_006722148.1  acyl-CoA-binding domain-containing protein 4 isoform X7

    UniProtKB/TrEMBL
    A0A0S2Z5W7
    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  11. XM_017025099.1XP_016880588.1  acyl-CoA-binding domain-containing protein 4 isoform X14

    UniProtKB/TrEMBL
    K7EM05
    Related
    ENSP00000466305.1, ENST00000592162.5
    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  12. XM_017025085.1XP_016880574.1  acyl-CoA-binding domain-containing protein 4 isoform X1

  13. XM_017025098.1XP_016880587.1  acyl-CoA-binding domain-containing protein 4 isoform X13

    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  14. XM_017025093.1XP_016880582.1  acyl-CoA-binding domain-containing protein 4 isoform X9

  15. XM_017025100.1XP_016880589.1  acyl-CoA-binding domain-containing protein 4 isoform X15

  16. XM_017025101.2XP_016880590.1  acyl-CoA-binding domain-containing protein 4 isoform X17

  17. XM_011525259.2XP_011523561.1  acyl-CoA-binding domain-containing protein 4 isoform X16

    Conserved Domains (2) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
    cl00464
    Location:103199
    URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...
  18. XM_011525261.2XP_011523563.1  acyl-CoA-binding domain-containing protein 4 isoform X18

    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  19. XM_017025086.1XP_016880575.1  acyl-CoA-binding domain-containing protein 4 isoform X1

  20. XM_017025092.2XP_016880581.1  acyl-CoA-binding domain-containing protein 4 isoform X8

    UniProtKB/Swiss-Prot
    Q8NC06
    UniProtKB/TrEMBL
    A0A0S2Z5Q0
    Conserved Domains (1) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
  21. XM_024450949.1XP_024306717.1  acyl-CoA-binding domain-containing protein 4 isoform X5

    Conserved Domains (2) summary
    pfam00887
    Location:1393
    ACBP; Acyl CoA binding protein
    cl26386
    Location:149294
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135704.1: Suppressed sequence

    Description
    NM_001135704.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
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