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FZD3 frizzled class receptor 3 [ Homo sapiens (human) ]

Gene ID: 7976, updated on 21-Dec-2019

Summary

Official Symbol
FZD3provided by HGNC
Official Full Name
frizzled class receptor 3provided by HGNC
Primary source
HGNC:HGNC:4041
See related
Ensembl:ENSG00000104290 MIM:606143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fz-3
Summary
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
Expression
Broad expression in brain (RPKM 6.0), ovary (RPKM 2.6) and 18 other tissues See more
Orthologs

Genomic context

See FZD3 in Genome Data Viewer
Location:
8p21.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (28494205..28574268)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28351722..28431785)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 178, pseudogene Neighboring gene F-box protein 16 Neighboring gene VISTA enhancer hs1329 Neighboring gene microRNA 4288 Neighboring gene RNA, 5S ribosomal pseudogene 259 Neighboring gene exostosin like glycosyltransferase 3 Neighboring gene EXTL3 antisense RNA 1 Neighboring gene integrator complex subunit 9 Neighboring gene ribosomal protein L36a pseudogene 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IC
Inferred by Curator
more info
PubMed 
Wnt-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation in midbrain IEA
Inferred from Electronic Annotation
more info
 
commissural neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
dopaminergic neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
establishment of planar polarity IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain morphogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mitotic cell cycle, embryonic ISS
Inferred from Sequence or Structural Similarity
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
planar cell polarity pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
serotonergic neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
sympathetic ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
filopodium tip IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
frizzled-3
Names
frizzled 3, seven transmembrane spanning receptor
frizzled family receptor 3
frizzled homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029723.1 RefSeqGene

    Range
    5008..85054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017412.4NP_059108.1  frizzled-3 precursor

    See identical proteins and their annotated locations for NP_059108.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB039723, AC011132, BU676090, DA250029
    Consensus CDS
    CCDS6069.1
    UniProtKB/Swiss-Prot
    Q9NPG1
    Related
    ENSP00000240093.3, ENST00000240093.8
    Conserved Domains (2) summary
    cd07449
    Location:24150
    CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
    cd15033
    Location:192512
    7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors
  2. NM_145866.1NP_665873.1  frizzled-3 precursor

    See identical proteins and their annotated locations for NP_665873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011132, AK291480, BU676090, DA250029
    Consensus CDS
    CCDS6069.1
    UniProtKB/Swiss-Prot
    Q9NPG1
    Related
    ENSP00000437489.1, ENST00000537916.2
    Conserved Domains (2) summary
    cd07449
    Location:24150
    CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
    cd15033
    Location:192512
    7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    28494205..28574268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013843.1XP_016869332.1  frizzled-3 isoform X3

  2. XM_017013844.1XP_016869333.1  frizzled-3 isoform X4

  3. XM_017013842.1XP_016869331.1  frizzled-3 isoform X2

  4. XM_017013841.1XP_016869330.1  frizzled-3 isoform X1

    Conserved Domains (2) summary
    pfam01534
    Location:126445
    Frizzled; Frizzled/Smoothened family membrane region
    cl02447
    Location:183
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

RNA

  1. XR_001745597.2 RNA Sequence

  2. XR_949476.2 RNA Sequence

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