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DHRS12 dehydrogenase/reductase 12 [ Homo sapiens (human) ]

Gene ID: 79758, updated on 12-Oct-2019

Summary

Official Symbol
DHRS12provided by HGNC
Official Full Name
dehydrogenase/reductase 12provided by HGNC
Primary source
HGNC:HGNC:25832
See related
Ensembl:ENSG00000102796 MIM:616163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR40C1
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in fat (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See DHRS12 in Genome Data Viewer
Location:
13q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (51767993..51804163, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52330614..52379667, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 413, pseudogene Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 1 Neighboring gene uncharacterized LOC107984561 Neighboring gene transmembrane protein 272 Neighboring gene coiled-coil domain containing 70

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 12
Names
dehydrogenase/reductase (SDR family) member 12
short-chain dehydrogenase/reductase family 40C member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031719.3NP_001026889.1  dehydrogenase/reductase SDR family member 12 isoform 1

    See identical proteins and their annotated locations for NP_001026889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL162377, BC009825, DB481446, R60032
    Consensus CDS
    CCDS31976.1
    UniProtKB/Swiss-Prot
    A0PJE2
    Related
    ENSP00000280056.2, ENST00000280056.6
    Conserved Domains (1) summary
    cl25409
    Location:33186
    SDR; Short-chain dehydrogenases/reductases (SDR)
  2. NM_001270424.1NP_001257353.1  dehydrogenase/reductase SDR family member 12 isoform 3

    See identical proteins and their annotated locations for NP_001257353.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region and 3' UTR, including the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 3) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AA831151, BC026024, DB481446
    Consensus CDS
    CCDS58292.1
    UniProtKB/Swiss-Prot
    A0PJE2
    Related
    ENSP00000411565.2, ENST00000444610.7
    Conserved Domains (2) summary
    cd09808
    Location:40293
    DHRS-12_like_SDR_c-like; human dehydrogenase/reductase SDR family member (DHRS)-12/FLJ13639-like, classical (c)-like SDRs
    PRK06138
    Location:40298
    PRK06138; short chain dehydrogenase; Provisional
  3. NM_024705.2NP_078981.1  dehydrogenase/reductase SDR family member 12 isoform 2

    See identical proteins and their annotated locations for NP_078981.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA831151, AK023701, DB481446
    Consensus CDS
    CCDS9430.1
    UniProtKB/Swiss-Prot
    A0PJE2
    Related
    ENSP00000218981.1, ENST00000218981.5
    Conserved Domains (1) summary
    cl21454
    Location:33232
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    51767993..51804163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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