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CCDC7 coiled-coil domain containing 7 [ Homo sapiens (human) ]

Gene ID: 79741, updated on 1-Jun-2020

Summary

Official Symbol
CCDC7provided by HGNC
Official Full Name
coiled-coil domain containing 7provided by HGNC
Primary source
HGNC:HGNC:26533
See related
Ensembl:ENSG00000216937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68
Expression
Biased expression in testis (RPKM 14.7) and thyroid (RPKM 0.4) See more
Orthologs

Genomic context

See CCDC7 in Genome Data Viewer
Location:
10p11.22
Exon count:
59
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (32446129..32882864)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (32735057..33171805)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1244, pseudogene Neighboring gene uncharacterized LOC101929431 Neighboring gene C1D nuclear receptor corepressor pseudogene 1 Neighboring gene uncharacterized LOC105376486 Neighboring gene small nucleolar RNA, H/ACA box 86 Neighboring gene integrin subunit beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13031, FLJ25419, FLJ32762, MGC26635, MGC35087, MGC149767, dJ1104A8.1, DKFZp686N0559, RP11-479G22.1

General protein information

Preferred Names
coiled-coil domain-containing protein 7; uncharacterized protein C10orf68
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001026383.3NP_001021554.1  coiled-coil domain-containing protein 7 isoform a

    See identical proteins and their annotated locations for NP_001021554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    BC042672, HY009015
    Consensus CDS
    CCDS7173.1
    UniProtKB/Swiss-Prot
    Q96M83
    Related
    ENSP00000277657.6, ENST00000277657.12
    Conserved Domains (2) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
    cl25732
    Location:113439
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001321115.2NP_001308044.1  uncharacterized protein C10orf68 isoform c

    Status: VALIDATED

    Source sequence(s)
    AA401575, AL354750, AL356053, AL365203, AL391839, AL591850
    Consensus CDS
    CCDS86081.1
    UniProtKB/Swiss-Prot
    Q96M83
    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  3. NM_145023.6NP_659460.3  coiled-coil domain-containing protein 7 isoform a

    See identical proteins and their annotated locations for NP_659460.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    BC022020, BC042672, HY009015
    Consensus CDS
    CCDS7173.1
    UniProtKB/Swiss-Prot
    Q96M83
    Related
    ENSP00000355078.5, ENST00000362006.11
    Conserved Domains (2) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
    cl25732
    Location:113439
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_109826.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate, internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057324, BC022020
    Related
    ENST00000476558.7
  2. NR_109827.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL354750, AL391839, BX647771, HY009015
    Related
    ENST00000545067.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    32446129..32882864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448168.1XP_024303936.1  uncharacterized protein C10orf68 isoform X28

    Conserved Domains (1) summary
    cl26511
    Location:6332
    Neuromodulin_N; Gap junction protein N-terminal region
  2. XM_011519663.1XP_011517965.1  uncharacterized protein C10orf68 isoform X1

    See identical proteins and their annotated locations for XP_011517965.1

    UniProtKB/Swiss-Prot
    Q96M83
    Related
    ENSP00000491655.1, ENST00000639629.1
    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  3. XM_011519667.1XP_011517969.1  uncharacterized protein C10orf68 isoform X7

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  4. XM_011519666.1XP_011517968.1  uncharacterized protein C10orf68 isoform X6

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  5. XM_011519671.1XP_011517973.1  uncharacterized protein C10orf68 isoform X11

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  6. XM_011519674.1XP_011517976.1  uncharacterized protein C10orf68 isoform X16

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  7. XM_017016640.1XP_016872129.1  uncharacterized protein C10orf68 isoform X15

  8. XM_017016638.1XP_016872127.1  uncharacterized protein C10orf68 isoform X5

  9. XM_017016639.1XP_016872128.1  uncharacterized protein C10orf68 isoform X12

  10. XM_011519673.1XP_011517975.1  uncharacterized protein C10orf68 isoform X14

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  11. XM_011519676.1XP_011517978.1  uncharacterized protein C10orf68 isoform X19

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  12. XM_011519672.1XP_011517974.1  uncharacterized protein C10orf68 isoform X13

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  13. XM_011519678.1XP_011517980.1  uncharacterized protein C10orf68 isoform X21

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  14. XM_011519670.1XP_011517972.1  uncharacterized protein C10orf68 isoform X10

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  15. XM_011519669.1XP_011517971.1  uncharacterized protein C10orf68 isoform X9

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  16. XM_011519675.1XP_011517977.1  uncharacterized protein C10orf68 isoform X17

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  17. XM_006717505.1XP_006717568.1  uncharacterized protein C10orf68 isoform X18

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  18. XM_006717506.1XP_006717569.1  uncharacterized protein C10orf68 isoform X22

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  19. XM_011519677.1XP_011517979.1  uncharacterized protein C10orf68 isoform X20

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  20. XM_011519679.1XP_011517981.1  uncharacterized protein C10orf68 isoform X23

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  21. XM_011519668.1XP_011517970.1  uncharacterized protein C10orf68 isoform X8

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  22. XM_024448166.1XP_024303934.1  uncharacterized protein C10orf68 isoform X4

    Conserved Domains (3) summary
    pfam15368
    Location:1159
    BioT2; Spermatogenesis family BioT2
    cl25732
    Location:113428
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:189925
    Neuromodulin_N; Gap junction protein N-terminal region
  23. XM_024448165.1XP_024303933.1  uncharacterized protein C10orf68 isoform X3

    Conserved Domains (2) summary
    pfam15368
    Location:1163
    BioT2; Spermatogenesis family BioT2
    cl26511
    Location:148630
    Neuromodulin_N; Gap junction protein N-terminal region
  24. XM_011519664.1XP_011517966.1  uncharacterized protein C10orf68 isoform X2

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  25. XM_017016644.1XP_016872133.1  uncharacterized protein C10orf68 isoform X27

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  26. XM_017016647.2XP_016872136.1  uncharacterized protein C10orf68 isoform X30

  27. XM_011519684.3XP_011517986.1  uncharacterized protein C10orf68 isoform X31

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  28. XM_011519686.2XP_011517988.1  uncharacterized protein C10orf68 isoform X34

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  29. XM_017016651.1XP_016872140.1  uncharacterized protein C10orf68 isoform X37

  30. XM_017016650.2XP_016872139.1  uncharacterized protein C10orf68 isoform X36

  31. XM_011519688.3XP_011517990.1  uncharacterized protein C10orf68 isoform X42

    Conserved Domains (1) summary
    pfam15368
    Location:1170
    BioT2; Spermatogenesis family BioT2
  32. XM_024448167.1XP_024303935.1  uncharacterized protein C10orf68 isoform X28

    Conserved Domains (1) summary
    cl26511
    Location:6332
    Neuromodulin_N; Gap junction protein N-terminal region
  33. XM_017016643.1XP_016872132.1  uncharacterized protein C10orf68 isoform X26

  34. XM_011519680.3XP_011517982.1  uncharacterized protein C10orf68 isoform X25

    Conserved Domains (1) summary
    PRK10929
    Location:172408
    PRK10929; putative mechanosensitive channel protein; Provisional
  35. XM_017016642.1XP_016872131.1  uncharacterized protein C10orf68 isoform X25

    Conserved Domains (1) summary
    PRK10929
    Location:172408
    PRK10929; putative mechanosensitive channel protein; Provisional
  36. XM_017016641.1XP_016872130.1  uncharacterized protein C10orf68 isoform X24

  37. XM_011519685.1XP_011517987.1  uncharacterized protein C10orf68 isoform X33

    Conserved Domains (1) summary
    PRK10929
    Location:31267
    PRK10929; putative mechanosensitive channel protein; Provisional
  38. XM_017016646.1XP_016872135.1  uncharacterized protein C10orf68 isoform X28

    Conserved Domains (1) summary
    cl26511
    Location:6332
    Neuromodulin_N; Gap junction protein N-terminal region
  39. XM_011519683.2XP_011517985.1  uncharacterized protein C10orf68 isoform X29

    Conserved Domains (1) summary
    PRK10929
    Location:85321
    PRK10929; putative mechanosensitive channel protein; Provisional
  40. XM_024448169.1XP_024303937.1  uncharacterized protein C10orf68 isoform X40

  41. XM_017016648.1XP_016872137.1  uncharacterized protein C10orf68 isoform X32

  42. XM_024448170.1XP_024303938.1  uncharacterized protein C10orf68 isoform X41

  43. XM_017016649.1XP_016872138.1  uncharacterized protein C10orf68 isoform X35

  44. XM_017016652.1XP_016872141.1  uncharacterized protein C10orf68 isoform X38

  45. XM_005252593.2XP_005252650.1  uncharacterized protein C10orf68 isoform X43

    Related
    ENSP00000364168.5, ENST00000375028.8
  46. XM_011519687.1XP_011517989.1  uncharacterized protein C10orf68 isoform X39

  47. XM_017016653.1XP_016872142.1  uncharacterized protein C10orf68 isoform X44

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024688.2: Suppressed sequence

    Description
    NM_024688.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein. It is now determined to be partial at the 5' end.
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