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SH3D21 SH3 domain containing 21 [ Homo sapiens (human) ]

Gene ID: 79729, updated on 13-May-2022

Summary

Official Symbol
SH3D21provided by HGNC
Official Full Name
SH3 domain containing 21provided by HGNC
Primary source
HGNC:HGNC:26236
See related
Ensembl:ENSG00000214193 AllianceGenome:HGNC:26236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf113
Summary
Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine (RPKM 7.0), skin (RPKM 5.6) and 23 other tissues See more
Orthologs
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Genomic context

See SH3D21 in Genome Data Viewer
Location:
1p34.3
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36306368..36330236)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36169214..36184220)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36771969..36786948)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene Sharpr-MPRA regulatory regions 10257 and 14041 Neighboring gene Sharpr-MPRA regulatory region 2392 Neighboring gene eva-1 homolog B Neighboring gene serine/threonine kinase 40 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:36839045-36840244 Neighboring gene uncharacterized LOC124904012

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22938

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
SH3 domain-containing protein 21
Names
SH3 domain-containing protein C1orf113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162530.2NP_001156002.1  SH3 domain-containing protein 21 isoform 1

    See identical proteins and their annotated locations for NP_001156002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL591845
    UniProtKB/Swiss-Prot
    A4FU49
    Related
    ENSP00000403476.2, ENST00000453908.8
    Conserved Domains (3) summary
    cd11874
    Location:87139
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:185239
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    cl17036
    Location:255
    SH3; Src Homology 3 domain superfamily
  2. NM_024676.5NP_078952.4  SH3 domain-containing protein 21 isoform 2

    See identical proteins and their annotated locations for NP_078952.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL591845
    Consensus CDS
    CCDS30674.2
    UniProtKB/Swiss-Prot
    A4FU49
    Related
    ENSP00000421294.1, ENST00000505871.7
    Conserved Domains (2) summary
    cd12142
    Location:74128
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    cl17036
    Location:128
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    36306368..36330236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002340.2XP_016857829.1  SH3 domain-containing protein 21 isoform X1

  2. XM_017002341.2XP_016857830.1  SH3 domain-containing protein 21 isoform X2

  3. XM_017002344.2XP_016857833.1  SH3 domain-containing protein 21 isoform X4

    Conserved Domains (4) summary
    cd11874
    Location:87139
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:185239
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    PHA03247
    Location:239675
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:255
    SH3; Src Homology 3 domain superfamily
  4. XM_017002345.2XP_016857834.1  SH3 domain-containing protein 21 isoform X5

  5. XM_017002342.3XP_016857831.1  SH3 domain-containing protein 21 isoform X3

    Conserved Domains (3) summary
    cd11874
    Location:87139
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:185239
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    cl17036
    Location:255
    SH3; Src Homology 3 domain superfamily
  6. XM_047430650.1XP_047286606.1  SH3 domain-containing protein 21 isoform X7

  7. XM_047430644.1XP_047286600.1  SH3 domain-containing protein 21 isoform X6

  8. XM_047430651.1XP_047286607.1  SH3 domain-containing protein 21 isoform X8

  9. XM_047430653.1XP_047286609.1  SH3 domain-containing protein 21 isoform X9

  10. XM_047430654.1XP_047286610.1  SH3 domain-containing protein 21 isoform X10

RNA

  1. XR_007063699.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    36169214..36184220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)