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THAP9 THAP domain containing 9 [ Homo sapiens (human) ]

Gene ID: 79725, updated on 5-Mar-2024

Summary

Official Symbol
THAP9provided by HGNC
Official Full Name
THAP domain containing 9provided by HGNC
Primary source
HGNC:HGNC:23192
See related
Ensembl:ENSG00000168152 MIM:612537; AllianceGenome:HGNC:23192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hTh9
Summary
Enables sequence-specific DNA binding activity and transposase activity. Involved in DNA integration and transposition, DNA-mediated. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 2.9), thyroid (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

See THAP9 in Genome Data Viewer
Location:
4q21.22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (82900735..82919969)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86229954..86249175)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83821888..83841122)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SEC31 homolog A, COPII coat complex component Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821333-83821852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821853-83822372 Neighboring gene THAP9 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 143 Neighboring gene small nucleolar RNA, C/D box 144 Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene ReSE screen-validated silencer GRCh37_chr4:83887737-83887940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15537 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:83933797-83934682 Neighboring gene RNA, U6 small nuclear 615, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21671 Neighboring gene Sharpr-MPRA regulatory region 7954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83956719-83957224 Neighboring gene COP9 signalosome subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23320, FLJ34093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transposase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transposase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA integration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA transposition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA transposition IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA transposase THAP9
Names
THAP domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317776.2NP_001304705.1  DNA transposase THAP9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA478110, AC021105, BC131722, DA317935
    Conserved Domains (1) summary
    pfam12017
    Location:72244
    Tnp_P_element; Transposase protein
  2. NM_024672.6NP_078948.3  DNA transposase THAP9 isoform 1

    See identical proteins and their annotated locations for NP_078948.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA478110, AC021105, DA317935, DB154392
    Consensus CDS
    CCDS3598.1
    UniProtKB/Swiss-Prot
    B3KRE2, Q59AC9, Q9H5L6
    Related
    ENSP00000305533.5, ENST00000302236.10
    Conserved Domains (2) summary
    pfam05485
    Location:488
    THAP; THAP domain
    pfam12017
    Location:216388
    Tnp_P_element; Transposase protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    82900735..82919969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416165.1XP_047272121.1  DNA transposase THAP9 isoform X1

  2. XM_047416166.1XP_047272122.1  DNA transposase THAP9 isoform X2

  3. XM_047416167.1XP_047272123.1  DNA transposase THAP9 isoform X2

  4. XM_047416168.1XP_047272124.1  DNA transposase THAP9 isoform X2

  5. XM_047416169.1XP_047272125.1  DNA transposase THAP9 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    86229954..86249175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350828.1XP_054206803.1  DNA transposase THAP9 isoform X1

  2. XM_054350829.1XP_054206804.1  DNA transposase THAP9 isoform X2

  3. XM_054350830.1XP_054206805.1  DNA transposase THAP9 isoform X2

  4. XM_054350831.1XP_054206806.1  DNA transposase THAP9 isoform X4