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CALCB calcitonin related polypeptide beta [ Homo sapiens (human) ]

Gene ID: 797, updated on 1-Aug-2020

Summary

Official Symbol
CALCBprovided by HGNC
Official Full Name
calcitonin related polypeptide betaprovided by HGNC
Primary source
HGNC:HGNC:1438
See related
Ensembl:ENSG00000175868 MIM:114160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CALC2; CGRP2; CGRP-II
Expression
Restricted expression toward thyroid (RPKM 12.3) See more
Orthologs

Genomic context

See CALCB in Genome Data Viewer
Location:
11p15.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (15073593..15078637)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (15095143..15103888)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene calcitonin related polypeptide alpha Neighboring gene olfactory receptor family 7 subfamily E member 41 pseudogene Neighboring gene INSC spindle orientation adaptor protein Neighboring gene VISTA enhancer hs692 Neighboring gene long intergenic non-protein coding RNA 2751

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcitonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcitonin gene-related peptide 2
Names
beta-CGRP
beta-type CGRP
calcitonin 2
calcitonin gene-related peptide II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000728.4NP_000719.1  calcitonin gene-related peptide 2 precursor

    See identical proteins and their annotated locations for NP_000719.1

    Status: VALIDATED

    Source sequence(s)
    AC090744, AI937230, BI668461, X02404
    Consensus CDS
    CCDS7820.1
    UniProtKB/Swiss-Prot
    P10092
    Related
    ENSP00000346017.5, ENST00000324229.11
    Conserved Domains (1) summary
    pfam00214
    Location:1123
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    15073593..15078637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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