U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RTL10 retrotransposon Gag like 10 [ Homo sapiens (human) ]

Gene ID: 79680, updated on 27-Nov-2024

Summary

Official Symbol
RTL10provided by HGNC
Official Full Name
retrotransposon Gag like 10provided by HGNC
Primary source
HGNC:HGNC:26112
See related
Ensembl:ENSG00000215012 MIM:620751; AllianceGenome:HGNC:26112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOP; C22orf29
Summary
Involved in mitochondrial outer membrane permeabilization and regulation of mitochondrial membrane potential. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in skin (RPKM 6.6), brain (RPKM 5.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RTL10 in Genome Data Viewer
Location:
22q11.21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (19846146..19854874, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20223015..20231743, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19833669..19842397, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19744621-19745499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19745779-19746288 Neighboring gene VISTA enhancer hs515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19750215-19751157 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19758419-19758590 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19764062-19764563 Neighboring gene T-box transcription factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19771036-19771536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19771537-19772037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19784762-19785467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19786734-19787315 Neighboring gene G protein subunit beta 1 like Neighboring gene ribosomal protein L7a pseudogene 70 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19794010-19794254 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19799088-19799263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19810945-19811459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19831532-19832045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19832046-19832558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19832559-19833071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19840887-19841505 Neighboring gene uncharacterized LOC124905080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19856194-19857136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19864911-19865712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19866515-19867316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19867317-19868118 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19868119-19868920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19868921-19869722 Neighboring gene thioredoxin reductase 2 Neighboring gene ribosomal protein L8 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein Bop
Names
BH3-only protein
retrotransposon Gag-like protein 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024627.6NP_078903.3  protein Bop

    See identical proteins and their annotated locations for NP_078903.3

    Status: VALIDATED

    Source sequence(s)
    AC000076, AK026924, BC011679, DA182195, DA757523
    Consensus CDS
    CCDS13769.1
    UniProtKB/Swiss-Prot
    A8K5E7, D3DX21, Q6MZM8, Q6N000, Q7L3V2, Q9H7A0
    Related
    ENSP00000330596.4, ENST00000328554.9
    Conserved Domains (1) summary
    pfam16297
    Location:104178
    DUF4939; Domain of unknown function (DUF4939)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    19846146..19854874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20223015..20231743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)