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MAP7D3 MAP7 domain containing 3 [ Homo sapiens (human) ]

Gene ID: 79649, updated on 3-Nov-2019

Summary

Official Symbol
MAP7D3provided by HGNC
Official Full Name
MAP7 domain containing 3provided by HGNC
Primary source
HGNC:HGNC:25742
See related
Ensembl:ENSG00000129680 MIM:300930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP3
Summary
The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]
Expression
Broad expression in testis (RPKM 6.8), fat (RPKM 4.8) and 24 other tissues See more
Orthologs

Genomic context

See MAP7D3 in Genome Data Viewer
Location:
Xq26.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (136213220..136256482, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135295379..135338641, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 6 pseudogene 4 Neighboring gene four and a half LIM domains 1 Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene adhesion G protein-coupled receptor G4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12401, FLJ12649

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MAP7 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016801.1 RefSeqGene

    Range
    10083..44669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173516.1NP_001166987.1  MAP7 domain-containing protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK301478, AL078638, AW139720, BC040518
    Consensus CDS
    CCDS55509.1
    UniProtKB/Swiss-Prot
    Q8IWC1
    Related
    ENSP00000359697.5, ENST00000370663.9
    Conserved Domains (2) summary
    pfam05672
    Location:565713
    MAP7; MAP7 (E-MAP-115) family
    pfam09805
    Location:667736
    Nop25; Nucleolar protein 12 (25kDa)
  2. NM_001173517.1NP_001166988.1  MAP7 domain-containing protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS and has an alternate 3' UTR exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL832120, AW206053, BC064350, DB454674
    Consensus CDS
    CCDS55508.1
    UniProtKB/Swiss-Prot
    Q8IWC1
    Related
    ENSP00000359695.1, ENST00000370661.5
    Conserved Domains (1) summary
    pfam05672
    Location:548696
    MAP7; MAP7 (E-MAP-115) family
  3. NM_024597.4NP_078873.2  MAP7 domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_078873.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK301478, AL078638, AL832120, AW139720, BC040518, DB454674
    Consensus CDS
    CCDS44004.1
    UniProtKB/Swiss-Prot
    Q8IWC1
    Related
    ENSP00000318086.9, ENST00000316077.14
    Conserved Domains (3) summary
    pfam05672
    Location:583731
    MAP7; MAP7 (E-MAP-115) family
    pfam15479
    Location:386469
    DUF4639; Domain of unknown function (DUF4639)
    cl28033
    Location:296539
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    136213220..136256482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452448.1XP_024308216.1  MAP7 domain-containing protein 3 isoform X1

    Conserved Domains (3) summary
    pfam05672
    Location:583731
    MAP7; MAP7 (E-MAP-115) family
    pfam15479
    Location:386469
    DUF4639; Domain of unknown function (DUF4639)
    cl28033
    Location:296539
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  2. XM_017029843.1XP_016885332.1  MAP7 domain-containing protein 3 isoform X3

  3. XM_005262472.2XP_005262529.1  MAP7 domain-containing protein 3 isoform X2

    Related
    ENSP00000359694.3, ENST00000370660.3
    Conserved Domains (2) summary
    pfam05672
    Location:582730
    MAP7; MAP7 (E-MAP-115) family
    pfam09805
    Location:684753
    Nop25; Nucleolar protein 12 (25kDa)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024765.1: Suppressed sequence

    Description
    NM_024765.1: This RefSeq was permanently suppressed because it is based on sequence which has a segment rearrange problem.
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