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MAP7D3 MAP7 domain containing 3 [ Homo sapiens (human) ]

Gene ID: 79649, updated on 3-Nov-2024

Summary

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Official Symbol
MAP7D3provided by HGNC
Official Full Name
MAP7 domain containing 3provided by HGNC
Primary source
HGNC:HGNC:25742
See related
Ensembl:ENSG00000129680 MIM:300930; AllianceGenome:HGNC:25742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP3
Summary
The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]
Expression
Broad expression in testis (RPKM 6.8), fat (RPKM 4.8) and 24 other tissues See more
Orthologs
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Genomic context

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See MAP7D3 in Genome Data Viewer
Location:
Xq26.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136213220..136256482, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134521607..134564861, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135295379..135338641, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:135225551-135226750 Neighboring gene four and a half LIM domains 1 Neighboring gene Sharpr-MPRA regulatory region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21026 Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene adhesion G protein-coupled receptor G4 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:135434931-135436130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:135468612-135469811

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis. Tala, et al. Theranostics, 2014. PMID 25161703, Free PMC Article
  2. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability. Sun X, et al. Cell Cycle, 2011 Nov 15. PMID 22142902
  3. C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin. Yadav S, et al. PLoS One, 2014. PMID 24927501, Free PMC Article
  4. MAP7 family proteins regulate kinesin-1 recruitment and activation. Hooikaas PJ, et al. J Cell Biol, 2019 Apr 1. PMID 30770434, Free PMC Article
  5. DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics. Kwon HJ, et al. J Cell Sci, 2016 Jul 15. PMID 27284004

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAP7 proteins are microtubule-tethered kinesin-1 activators, with which the motor transiently interacts as it moves along microtubules.
    Title: MAP7 family proteins regulate kinesin-1 recruitment and activation.
  2. Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle.
    Title: DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics.
  3. the amino-terminal region mediated the interaction of Mdp3 with histone deacetylase 6 (HDAC6), in addition to its association with tubulin and microtubules.
    Title: Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules.
  4. Results have identified a new microtubule binding region in MAP7D3, formed by the conserved MAP7 domain and the C-terminal tail, which can bind to microtubules and promote their assembly and stability.
    Title: C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin.
  5. A critical role for Mdp3 in the growth and metastasis of breast cancer.
    Title: Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis.
  6. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability.
    Title: Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12401, FLJ12649

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAP7 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016801.1 RefSeqGene

    Range
    10083..44669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173516.1 → NP_001166987.1  MAP7 domain-containing protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK301478, AL078638, AW139720, BC040518
    Consensus CDS
    CCDS55509.1
    UniProtKB/TrEMBL
    A0A0A0MRP0
    Related
    ENSP00000359697.5, ENST00000370663.9
    Conserved Domains (2) summary
    pfam05672
    Location:565 → 713
    MAP7; MAP7 (E-MAP-115) family
    pfam09805
    Location:667 → 736
    Nop25; Nucleolar protein 12 (25kDa)

  2. NM_001173517.2 → NP_001166988.1  MAP7 domain-containing protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS and has an alternate 3' UTR exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL832120, AW206053, BC064350, DB454674
    Consensus CDS
    CCDS55508.1
    UniProtKB/TrEMBL
    A0A0A0MRP0
    Related
    ENSP00000359695.1, ENST00000370661.5
    Conserved Domains (1) summary
    pfam05672
    Location:548 → 696
    MAP7; MAP7 (E-MAP-115) family

  3. NM_024597.4 → NP_078873.2  MAP7 domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_078873.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK301478, AL078638, AL832120, AW139720, BC040518, DB454674
    Consensus CDS
    CCDS44004.1
    UniProtKB/Swiss-Prot
    A2A2J0, A6NCZ7, A6NHR4, B4DWD2, H7BY77, Q5JXI5, Q5JXI6, Q6P2S1, Q8IWC1, Q9H9M8
    UniProtKB/TrEMBL
    A0A0A0MRP0
    Related
    ENSP00000318086.9, ENST00000316077.14
    Conserved Domains (3) summary
    pfam05672
    Location:583 → 731
    MAP7; MAP7 (E-MAP-115) family
    pfam15479
    Location:386 → 469
    DUF4639; Domain of unknown function (DUF4639)
    cl28033
    Location:296 → 539
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    136213220..136256482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    134521607..134564861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024765.1: Suppressed sequence

    Description
    NM_024765.1: This RefSeq was permanently suppressed because it is based on sequence which has a segment rearrange problem.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWC1.2 GenPept UniProtKB/Swiss-Prot:Q8IWC1

Gene LinkOut

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