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CCNJL cyclin J like [ Homo sapiens (human) ]

Gene ID: 79616, updated on 11-Jun-2021

Summary

Official Symbol
CCNJLprovided by HGNC
Official Full Name
cyclin J likeprovided by HGNC
Primary source
HGNC:HGNC:25876
See related
Ensembl:ENSG00000135083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 4.2), lung (RPKM 2.2) and 18 other tissues See more
Orthologs
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Genomic context

See CCNJL in Genome Data Viewer
Location:
5q33.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160249083..160339570, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159676090..159766577, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 721 Neighboring gene FABP6 antisense RNA 1 Neighboring gene fatty acid binding protein 6 Neighboring gene uncharacterized LOC105377691 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene SNRPE pseudogene 1 Neighboring gene C1q and TNF related 2 Neighboring gene zinc finger BED-type containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308173.3NP_001295102.1  cyclin-J-like protein isoform b

    See identical proteins and their annotated locations for NP_001295102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC112191, AK302823, BC013353, BF111450
    Consensus CDS
    CCDS78082.1
    UniProtKB/Swiss-Prot
    Q8IV13
    UniProtKB/TrEMBL
    B4DZA8
    Related
    ENSP00000257536.7, ENST00000257536.13
    Conserved Domains (2) summary
    pfam02984
    Location:145247
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:14107
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  2. NM_024565.8NP_078841.3  cyclin-J-like protein isoform a

    See identical proteins and their annotated locations for NP_078841.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC112191, BC013353, BC035871, BF111450
    Consensus CDS
    CCDS4350.2
    UniProtKB/Swiss-Prot
    Q8IV13
    UniProtKB/TrEMBL
    B4DZA8
    Related
    ENSP00000377547.3, ENST00000393977.7
    Conserved Domains (2) summary
    pfam02984
    Location:193295
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:1493
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RNA

  1. NR_131769.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112191, AK131381, AK294000, BF111450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    160249083..160339570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534646.3XP_011532948.1  cyclin-J-like protein isoform X6

    See identical proteins and their annotated locations for XP_011532948.1

    Related
    ENSP00000446367.2, ENST00000541762.5
    Conserved Domains (1) summary
    pfam02984
    Location:123230
    Cyclin_C; Cyclin, C-terminal domain
  2. XM_017009847.1XP_016865336.1  cyclin-J-like protein isoform X3

  3. XM_017009848.1XP_016865337.1  cyclin-J-like protein isoform X5

    Conserved Domains (2) summary
    pfam02984
    Location:75177
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:137
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  4. XM_006714917.4XP_006714980.1  cyclin-J-like protein isoform X2

    Conserved Domains (2) summary
    cd00043
    Location:3590
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam02984
    Location:190292
    Cyclin_C; Cyclin, C-terminal domain
  5. XM_011534647.3XP_011532949.1  cyclin-J-like protein isoform X4

    Conserved Domains (1) summary
    pfam02984
    Location:87189
    Cyclin_C; Cyclin, C-terminal domain

RNA

  1. XR_427810.4 RNA Sequence

  2. XR_427811.3 RNA Sequence

    Related
    ENST00000643836.1
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