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PGBD5 piggyBac transposable element derived 5 [ Homo sapiens (human) ]

Gene ID: 79605, updated on 13-Mar-2020

Summary

Official Symbol
PGBD5provided by HGNC
Official Full Name
piggyBac transposable element derived 5provided by HGNC
Primary source
HGNC:HGNC:19405
See related
Ensembl:ENSG00000177614 MIM:616791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, May 2010]
Expression
Biased expression in brain (RPKM 13.1), adrenal (RPKM 4.4) and 9 other tissues See more
Orthologs

Genomic context

See PGBD5 in Genome Data Viewer
Location:
1q42.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (230314490..230426332, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (230457392..230561674, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1736 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 2 Neighboring gene Sharpr-MPRA regulatory region 1224 Neighboring gene Sharpr-MPRA regulatory region 8330 Neighboring gene uncharacterized LOC105373164 Neighboring gene uncharacterized LOC105373165

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11413, DKFZp761A0620

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
transposase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transposase activity IDA
Inferred from Direct Assay
more info
PubMed 
transposase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
non-replicative transposition, DNA-mediated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-replicative transposition, DNA-mediated IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
piggyBac transposable element-derived protein 5
Names
piggyBac domain related protein 5
piggyBac transposase 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258311.2NP_001245240.1  piggyBac transposable element-derived protein 5

    See identical proteins and their annotated locations for NP_001245240.1

    Status: REVIEWED

    Source sequence(s)
    AL133516, AL691479, BC013901, BC036865, CX757968
    Consensus CDS
    CCDS81430.1
    UniProtKB/Swiss-Prot
    Q8N414
    Related
    ENSP00000375733.2, ENST00000391860.7
    Conserved Domains (1) summary
    pfam13843
    Location:121487
    DDE_Tnp_1_7; Transposase IS4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    230314490..230426332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024554.3: Suppressed sequence

    Description
    NM_024554.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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