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OBI1 ORC ubiquitin ligase 1 [ Homo sapiens (human) ]

Gene ID: 79596, updated on 12-Oct-2019

Summary

Official Symbol
OBI1provided by HGNC
Official Full Name
ORC ubiquitin ligase 1provided by HGNC
Primary source
HGNC:HGNC:20308
See related
Ensembl:ENSG00000152193 MIM:615906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF219; C13orf7
Expression
Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 4.8) and 25 other tissues See more
Orthologs

Genomic context

See OBI1 in Genome Data Viewer
Location:
13q31.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (78614286..78659165, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (79188421..79233314, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene OBI1 antisense RNA 1 Neighboring gene elongin C pseudogene 23 Neighboring gene uncharacterized LOC780529 Neighboring gene POU class 4 homeobox 1 Neighboring gene uncharacterized LOC105370272 Neighboring gene ribosomal protein L21 pseudogene 111 Neighboring gene long intergenic non-protein coding RNA 331

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13449, FLJ25774, DKFZp686A01276, DKFZp686N15250, DKFZp686O03173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ORC ubiquitin ligase 1; RING finger protein 219
Names
ring finger protein 219
NP_078822.3
XP_011533527.1
XP_024305178.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024546.4NP_078822.3  ORC ubiquitin ligase 1

    See identical proteins and their annotated locations for NP_078822.3

    Status: VALIDATED

    Source sequence(s)
    AK023511, BC028586, BI550796, BM674566
    Consensus CDS
    CCDS31997.1
    UniProtKB/Swiss-Prot
    Q5W0B1
    Related
    ENSP00000282003.6, ENST00000282003.7
    Conserved Domains (1) summary
    cd00162
    Location:1759
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    78614286..78659165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535225.1XP_011533527.1  RING finger protein 219 isoform X1

    See identical proteins and their annotated locations for XP_011533527.1

    Conserved Domains (2) summary
    TIGR04211
    Location:29132
    SH3_and_anchor; SH3 domain protein
    cl25602
    Location:83189
    DUF3552; Domain of unknown function (DUF3552)
  2. XM_024449410.1XP_024305178.1  RING finger protein 219 isoform X1

    Conserved Domains (2) summary
    TIGR04211
    Location:29132
    SH3_and_anchor; SH3 domain protein
    cl25602
    Location:83189
    DUF3552; Domain of unknown function (DUF3552)
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